Batf controls the global regulators of class switch recombination in both B and T cells

The transcription factor Batf controls T(H)17 differentiation by regulating the expression of both RORγt and RORγt target genes such as Il17. Here, we report the mechanism by which Batf controls in vivo class switch recombination (CSR). In T cells, Batf directly controls expression of the transcript...

Descripción completa

Detalles Bibliográficos
Autores principales: Ise, Wataru, Kohyama, Masako, Schraml, Barbara U., Zhang, Tingting, Schwer, Bjoern, Basu, Uttiya, Alt, Frederick W., Tang, Jun, Oltz, Eugene M., Murphy, Theresa L., Murphy, Kenneth M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117275/
https://www.ncbi.nlm.nih.gov/pubmed/21572431
http://dx.doi.org/10.1038/ni.2037
_version_ 1782206312158855168
author Ise, Wataru
Kohyama, Masako
Schraml, Barbara U.
Zhang, Tingting
Schwer, Bjoern
Basu, Uttiya
Alt, Frederick W.
Tang, Jun
Oltz, Eugene M.
Murphy, Theresa L.
Murphy, Kenneth M.
author_facet Ise, Wataru
Kohyama, Masako
Schraml, Barbara U.
Zhang, Tingting
Schwer, Bjoern
Basu, Uttiya
Alt, Frederick W.
Tang, Jun
Oltz, Eugene M.
Murphy, Theresa L.
Murphy, Kenneth M.
author_sort Ise, Wataru
collection PubMed
description The transcription factor Batf controls T(H)17 differentiation by regulating the expression of both RORγt and RORγt target genes such as Il17. Here, we report the mechanism by which Batf controls in vivo class switch recombination (CSR). In T cells, Batf directly controls expression of the transcription factors Bcl-6 and c-Maf, both of which are needed for development of T follicular helper (T(FH)) cells. Restoring T(FH) activity to Batf(−/−) T cells in vivo requires co-expression of both Bcl-6 and c-Maf. In B cells, Batf directly controls the expression of both activation-induced cytidine deaminase (AID) and of I(H)-C(H) germline transcripts. Thus, Batf functions at multiple hierarchical levels across two cell types to globally regulate in vivo switched antibody responses.
format Online
Article
Text
id pubmed-3117275
institution National Center for Biotechnology Information
language English
publishDate 2011
record_format MEDLINE/PubMed
spelling pubmed-31172752011-12-01 Batf controls the global regulators of class switch recombination in both B and T cells Ise, Wataru Kohyama, Masako Schraml, Barbara U. Zhang, Tingting Schwer, Bjoern Basu, Uttiya Alt, Frederick W. Tang, Jun Oltz, Eugene M. Murphy, Theresa L. Murphy, Kenneth M. Nat Immunol Article The transcription factor Batf controls T(H)17 differentiation by regulating the expression of both RORγt and RORγt target genes such as Il17. Here, we report the mechanism by which Batf controls in vivo class switch recombination (CSR). In T cells, Batf directly controls expression of the transcription factors Bcl-6 and c-Maf, both of which are needed for development of T follicular helper (T(FH)) cells. Restoring T(FH) activity to Batf(−/−) T cells in vivo requires co-expression of both Bcl-6 and c-Maf. In B cells, Batf directly controls the expression of both activation-induced cytidine deaminase (AID) and of I(H)-C(H) germline transcripts. Thus, Batf functions at multiple hierarchical levels across two cell types to globally regulate in vivo switched antibody responses. 2011-05-15 2011-06 /pmc/articles/PMC3117275/ /pubmed/21572431 http://dx.doi.org/10.1038/ni.2037 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Ise, Wataru
Kohyama, Masako
Schraml, Barbara U.
Zhang, Tingting
Schwer, Bjoern
Basu, Uttiya
Alt, Frederick W.
Tang, Jun
Oltz, Eugene M.
Murphy, Theresa L.
Murphy, Kenneth M.
Batf controls the global regulators of class switch recombination in both B and T cells
title Batf controls the global regulators of class switch recombination in both B and T cells
title_full Batf controls the global regulators of class switch recombination in both B and T cells
title_fullStr Batf controls the global regulators of class switch recombination in both B and T cells
title_full_unstemmed Batf controls the global regulators of class switch recombination in both B and T cells
title_short Batf controls the global regulators of class switch recombination in both B and T cells
title_sort batf controls the global regulators of class switch recombination in both b and t cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117275/
https://www.ncbi.nlm.nih.gov/pubmed/21572431
http://dx.doi.org/10.1038/ni.2037
work_keys_str_mv AT isewataru batfcontrolstheglobalregulatorsofclassswitchrecombinationinbothbandtcells
AT kohyamamasako batfcontrolstheglobalregulatorsofclassswitchrecombinationinbothbandtcells
AT schramlbarbarau batfcontrolstheglobalregulatorsofclassswitchrecombinationinbothbandtcells
AT zhangtingting batfcontrolstheglobalregulatorsofclassswitchrecombinationinbothbandtcells
AT schwerbjoern batfcontrolstheglobalregulatorsofclassswitchrecombinationinbothbandtcells
AT basuuttiya batfcontrolstheglobalregulatorsofclassswitchrecombinationinbothbandtcells
AT altfrederickw batfcontrolstheglobalregulatorsofclassswitchrecombinationinbothbandtcells
AT tangjun batfcontrolstheglobalregulatorsofclassswitchrecombinationinbothbandtcells
AT oltzeugenem batfcontrolstheglobalregulatorsofclassswitchrecombinationinbothbandtcells
AT murphytheresal batfcontrolstheglobalregulatorsofclassswitchrecombinationinbothbandtcells
AT murphykennethm batfcontrolstheglobalregulatorsofclassswitchrecombinationinbothbandtcells

Ejemplares similares