Pharmacological inhibition of NF-κB prolongs lifespan of Drosophila melanogaster

Aging is associated with NF-κB-dependent pro-inflammation. Here we demonstrated that inhibition of NF-κB with pyrrolidine dithiocarbamate increases the median lifespan (13-20%) and the age of 90% mortality (11-14%) in Drosophila melanogaster females and males, respectively.

Detalles Bibliográficos
Autores principales: Moskalev, Alexey, Shaposhnikov, Mikhail
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2011
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117454/
https://www.ncbi.nlm.nih.gov/pubmed/21483034
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author Moskalev, Alexey
Shaposhnikov, Mikhail
author_facet Moskalev, Alexey
Shaposhnikov, Mikhail
author_sort Moskalev, Alexey
collection PubMed
description Aging is associated with NF-κB-dependent pro-inflammation. Here we demonstrated that inhibition of NF-κB with pyrrolidine dithiocarbamate increases the median lifespan (13-20%) and the age of 90% mortality (11-14%) in Drosophila melanogaster females and males, respectively.
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spelling pubmed-31174542011-06-20 Pharmacological inhibition of NF-κB prolongs lifespan of Drosophila melanogaster Moskalev, Alexey Shaposhnikov, Mikhail Aging (Albany NY) Research Paper Aging is associated with NF-κB-dependent pro-inflammation. Here we demonstrated that inhibition of NF-κB with pyrrolidine dithiocarbamate increases the median lifespan (13-20%) and the age of 90% mortality (11-14%) in Drosophila melanogaster females and males, respectively. Impact Journals LLC 2011-03-28 /pmc/articles/PMC3117454/ /pubmed/21483034 Text en Copyright: © 2011 Moskalev and Shaposhnikov http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
spellingShingle Research Paper
Moskalev, Alexey
Shaposhnikov, Mikhail
Pharmacological inhibition of NF-κB prolongs lifespan of Drosophila melanogaster
title Pharmacological inhibition of NF-κB prolongs lifespan of Drosophila melanogaster
title_full Pharmacological inhibition of NF-κB prolongs lifespan of Drosophila melanogaster
title_fullStr Pharmacological inhibition of NF-κB prolongs lifespan of Drosophila melanogaster
title_full_unstemmed Pharmacological inhibition of NF-κB prolongs lifespan of Drosophila melanogaster
title_short Pharmacological inhibition of NF-κB prolongs lifespan of Drosophila melanogaster
title_sort pharmacological inhibition of nf-κb prolongs lifespan of drosophila melanogaster
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117454/
https://www.ncbi.nlm.nih.gov/pubmed/21483034
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AT shaposhnikovmikhail pharmacologicalinhibitionofnfkbprolongslifespanofdrosophilamelanogaster

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