Differential control of Eg5-dependent centrosome separation by Plk1 and Cdk1

Cyclin-dependent kinase 1 (Cdk1) is thought to trigger centrosome separation in late G2 phase by phosphorylating the motor protein Eg5 at Thr927. However, the precise control mechanism of centrosome separation remains to be understood. Here, we report that in G2 phase polo-like kinase 1 (Plk1) can t...

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Detalles Bibliográficos
Autores principales: Smith, Ewan, Hégarat, Nadia, Vesely, Clare, Roseboom, Isaac, Larch, Chris, Streicher, Hansjörg, Straatman, Kornelis, Flynn, Helen, Skehel, Mark, Hirota, Toru, Kuriyama, Ryoko, Hochegger, Helfrid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Molecular Biology Organization 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117641/
https://www.ncbi.nlm.nih.gov/pubmed/21522128
http://dx.doi.org/10.1038/emboj.2011.120

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