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Degenerative processes in bioprosthetic mitral valves in juvenile pigs

BACKGROUND: Glutaraldehyde-treated bioprosthetic heart valves are commonly used for replacement of diseased heart valves. However, calcification and wear limit their durability, and the development of new and improved bioprosthetic valve designs is needed and must be evaluated in a reliable animal m...

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Autores principales: Honge, Jesper L, Funder, Jonas A, Pedersen, Torben B, Kronborg, Mads B, Hasenkam, J Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117695/
https://www.ncbi.nlm.nih.gov/pubmed/21569636
http://dx.doi.org/10.1186/1749-8090-6-72
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author Honge, Jesper L
Funder, Jonas A
Pedersen, Torben B
Kronborg, Mads B
Hasenkam, J Michael
author_facet Honge, Jesper L
Funder, Jonas A
Pedersen, Torben B
Kronborg, Mads B
Hasenkam, J Michael
author_sort Honge, Jesper L
collection PubMed
description BACKGROUND: Glutaraldehyde-treated bioprosthetic heart valves are commonly used for replacement of diseased heart valves. However, calcification and wear limit their durability, and the development of new and improved bioprosthetic valve designs is needed and must be evaluated in a reliable animal model. We studied glutaraldehyde-treated valves 6 months after implantation to evaluate bioprosthetic valve complications in the mitral position in juvenile pigs. MATERIALS: The study material comprised eight, 5-month old, 60-kg pigs. All pigs received a size 27, glutaraldehyde-treated, stented, Carpentier-Edwards S.A.V. mitral valve prosthesis. After six months, echocardiography was performed, and the valves explanted for gross examination, high resolution X-ray, and histological evaluation. RESULTS: Five pigs survived the follow-up period. Preexplant echocardiography revealed a median peak and mean velocity of 1.61 m/s (range: 1.17-2.00) and 1.20 (SD = ±0.25), respectively, and a median peak and mean pressure difference of 10.42 mmHg (range: 5.83-16.55) and 6.51 mmHg (SD = ±2.57), respectively. Gross examination showed minor thrombotic depositions at two commissures in two valves and at all three commissures in three valves. High resolution X-ray imaging revealed different degrees of calcification in all explanted valves, primarily in the commissural and belly areas. In all valves, histological evaluation demonstrated various degrees of fibrous sheath formation, limited immunological infiltration, and no overgrowth of host endothelium. CONCLUSIONS: Bioprosthetic glutaraldehyde-treated mitral valves can be implanted into the mitral position in pigs and function after 6 months. Echocardiographic data, calcification, and histological examinations were comparable to results obtained in sheep models and human demonstrating the suitability of the porcine model.
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spelling pubmed-31176952011-06-18 Degenerative processes in bioprosthetic mitral valves in juvenile pigs Honge, Jesper L Funder, Jonas A Pedersen, Torben B Kronborg, Mads B Hasenkam, J Michael J Cardiothorac Surg Research Article BACKGROUND: Glutaraldehyde-treated bioprosthetic heart valves are commonly used for replacement of diseased heart valves. However, calcification and wear limit their durability, and the development of new and improved bioprosthetic valve designs is needed and must be evaluated in a reliable animal model. We studied glutaraldehyde-treated valves 6 months after implantation to evaluate bioprosthetic valve complications in the mitral position in juvenile pigs. MATERIALS: The study material comprised eight, 5-month old, 60-kg pigs. All pigs received a size 27, glutaraldehyde-treated, stented, Carpentier-Edwards S.A.V. mitral valve prosthesis. After six months, echocardiography was performed, and the valves explanted for gross examination, high resolution X-ray, and histological evaluation. RESULTS: Five pigs survived the follow-up period. Preexplant echocardiography revealed a median peak and mean velocity of 1.61 m/s (range: 1.17-2.00) and 1.20 (SD = ±0.25), respectively, and a median peak and mean pressure difference of 10.42 mmHg (range: 5.83-16.55) and 6.51 mmHg (SD = ±2.57), respectively. Gross examination showed minor thrombotic depositions at two commissures in two valves and at all three commissures in three valves. High resolution X-ray imaging revealed different degrees of calcification in all explanted valves, primarily in the commissural and belly areas. In all valves, histological evaluation demonstrated various degrees of fibrous sheath formation, limited immunological infiltration, and no overgrowth of host endothelium. CONCLUSIONS: Bioprosthetic glutaraldehyde-treated mitral valves can be implanted into the mitral position in pigs and function after 6 months. Echocardiographic data, calcification, and histological examinations were comparable to results obtained in sheep models and human demonstrating the suitability of the porcine model. BioMed Central 2011-05-15 /pmc/articles/PMC3117695/ /pubmed/21569636 http://dx.doi.org/10.1186/1749-8090-6-72 Text en Copyright ©2011 Honge et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Honge, Jesper L
Funder, Jonas A
Pedersen, Torben B
Kronborg, Mads B
Hasenkam, J Michael
Degenerative processes in bioprosthetic mitral valves in juvenile pigs
title Degenerative processes in bioprosthetic mitral valves in juvenile pigs
title_full Degenerative processes in bioprosthetic mitral valves in juvenile pigs
title_fullStr Degenerative processes in bioprosthetic mitral valves in juvenile pigs
title_full_unstemmed Degenerative processes in bioprosthetic mitral valves in juvenile pigs
title_short Degenerative processes in bioprosthetic mitral valves in juvenile pigs
title_sort degenerative processes in bioprosthetic mitral valves in juvenile pigs
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117695/
https://www.ncbi.nlm.nih.gov/pubmed/21569636
http://dx.doi.org/10.1186/1749-8090-6-72
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