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A systems biology approach to dynamic modeling and inter-subject variability of statin pharmacokinetics in human hepatocytes

BACKGROUND: The individual character of pharmacokinetics is of great importance in the risk assessment of new drug leads in pharmacological research. Amongst others, it is severely influenced by the properties and inter-individual variability of the enzymes and transporters of the drug detoxificatio...

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Detalles Bibliográficos
Autores principales:	Bucher, Joachim, Riedmaier, Stephan, Schnabel, Anke, Marcus, Katrin, Vacun, Gabriele, Weiss, Thomas S, Thasler, Wolfgang E, Nüssler, Andreas K, Zanger, Ulrich M, Reuss, Matthias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117731/ https://www.ncbi.nlm.nih.gov/pubmed/21548957 http://dx.doi.org/10.1186/1752-0509-5-66

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