A comparative study on the efficacy of a commercial fibrin adhesive (Tisseel(®)) vis-à-vis silk suture on wound closure following periodontal surgical procedures

AIMS AND OBJECTIVES: To evaluate the efficacy of fibrin adhesive sealant (Tisseel(®)), a human biological tissue adhesive, as compared to conventional suture placement in pocket elimination and mucogingival surgical procedures. MATERIALS AND METHODS: The study sample consisted of 25 patients (10 male and 15 female patients), in the age group of 25-40 years, with localized periodontitis in relation to the anterior region of the maxilla and mandible. They were divided into three surgical groups: Group I, Group II and Group III. Each of these groups was further divided into control and experimental groups. In all the control groups, the flaps/grafts were approximated with 4-0 black braided silk. In the experimental groups, the flaps/grafts were approximated with fibrin adhesive sealant (Tisseel(;)). Clinical parameters were taken pre-operatively.operatively and post-operatively on the 1(st), 2(nd), 3(rd), 7(th), and 10(th), day. RESULTS: The Fibrin Adhesive System (FAS) showed superior results in all the parameters measured, i.e., hemostasis, fixation of tissues, reduction in plaque and gingival index and probing depth postoperatively. CONCLUSION: The results of this study indicate that periodontal surgery using FAS enhances various periodontal regenerative surgical procedures.