Surface expression and limited proteolysis of ADAM10 are increased by a dominant negative inhibitor of dynamin

BACKGROUND: The amyloid precursor protein (APP) is cleaved by β- and γ-secretases to generate toxic amyloid β (Aβ) peptides. Alternatively, α-secretases cleave APP within the Aβ domain, precluding Aβ formation and releasing the soluble ectodomain, sAPPα. We previously showed that inhibition of the G...

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Detalles Bibliográficos
Autores principales: Carey, Robyn M, Blusztajn, Jan K, Slack, Barbara E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118186/
https://www.ncbi.nlm.nih.gov/pubmed/21586144
http://dx.doi.org/10.1186/1471-2121-12-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118186/
https://www.ncbi.nlm.nih.gov/pubmed/21586144
http://dx.doi.org/10.1186/1471-2121-12-20

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