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Surface expression and limited proteolysis of ADAM10 are increased by a dominant negative inhibitor of dynamin
BACKGROUND: The amyloid precursor protein (APP) is cleaved by β- and γ-secretases to generate toxic amyloid β (Aβ) peptides. Alternatively, α-secretases cleave APP within the Aβ domain, precluding Aβ formation and releasing the soluble ectodomain, sAPPα. We previously showed that inhibition of the G...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118186/ https://www.ncbi.nlm.nih.gov/pubmed/21586144 http://dx.doi.org/10.1186/1471-2121-12-20 |