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MLH1 Deficiency Enhances Tumor Cell Sensitivity to Ganciclovir

Suicide gene therapy with herpes simplex virus thymidine kinase and ganciclovir is notable for producing multi-log cytotoxicity in a unique pattern of delayed cytotoxicity in S-phase. Because hydroxyurea, a ribonucleotide reductase inhibitor that activates mismatch repair, can increase sensitivity t...

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Detalles Bibliográficos
Autores principales:	O’Konek, Jessica J., Boucher, Paul D., Iacco, Anthony A., Wilson, Thomas E., Shewach, Donna S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118284/ https://www.ncbi.nlm.nih.gov/pubmed/19300472 http://dx.doi.org/10.1038/cgt.2009.16

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