Curcumin reduces expression of Bcl-2, leading to apoptosis in daunorubicin-insensitive CD34(+ )acute myeloid leukemia cell lines and primary sorted CD34(+ )acute myeloid leukemia cells

BACKGROUND: Acute myeloid leukemia (AML) is an immunophenotypically heterogenous malignant disease, in which CD34 positivity is associated with poor prognosis. CD34(+ )AML cells are 10-15-fold more resistant to daunorubicin (DNR) than CD34(- )AML cells. Curcumin is a major component of turmeric that...

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Detalles Bibliográficos
Autores principales: Rao, Jia, Xu, Duo-Rong, Zheng, Fei-Meng, Long, Zi-Jie, Huang, Sheng-Shan, Wu, Xing, Zhou, Wei-Hua, Huang, Ren-Wei, Liu, Quentin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118333/
https://www.ncbi.nlm.nih.gov/pubmed/21595920
http://dx.doi.org/10.1186/1479-5876-9-71

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