Cargando…
Long-term potentiation and long-term depression: a clinical perspective
Long-term potentiation and long-term depression are enduring changes in synaptic strength, induced by specific patterns of synaptic activity, that have received much attention as cellular models of information storage in the central nervous system. Work in a number of brain regions, from the spinal...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118435/ https://www.ncbi.nlm.nih.gov/pubmed/21779718 http://dx.doi.org/10.1590/S1807-59322011001300002 |
_version_ | 1782206473191817216 |
---|---|
author | Bliss, Timothy V.P. Cooke, Sam F |
author_facet | Bliss, Timothy V.P. Cooke, Sam F |
author_sort | Bliss, Timothy V.P. |
collection | PubMed |
description | Long-term potentiation and long-term depression are enduring changes in synaptic strength, induced by specific patterns of synaptic activity, that have received much attention as cellular models of information storage in the central nervous system. Work in a number of brain regions, from the spinal cord to the cerebral cortex, and in many animal species, ranging from invertebrates to humans, has demonstrated a reliable capacity for chemical synapses to undergo lasting changes in efficacy in response to a variety of induction protocols. In addition to their physiological relevance, long-term potentiation and depression may have important clinical applications. A growing insight into the molecular mechanisms underlying these processes, and technological advances in non-invasive manipulation of brain activity, now puts us at the threshold of harnessing long-term potentiation and depression and other forms of synaptic, cellular and circuit plasticity to manipulate synaptic strength in the human nervous system. Drugs may be used to erase or treat pathological synaptic states and non-invasive stimulation devices may be used to artificially induce synaptic plasticity to ameliorate conditions arising from disrupted synaptic drive. These approaches hold promise for the treatment of a variety of neurological conditions, including neuropathic pain, epilepsy, depression, amblyopia, tinnitus and stroke. |
format | Online Article Text |
id | pubmed-3118435 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo |
record_format | MEDLINE/PubMed |
spelling | pubmed-31184352011-06-22 Long-term potentiation and long-term depression: a clinical perspective Bliss, Timothy V.P. Cooke, Sam F Clinics (Sao Paulo) Editorial Long-term potentiation and long-term depression are enduring changes in synaptic strength, induced by specific patterns of synaptic activity, that have received much attention as cellular models of information storage in the central nervous system. Work in a number of brain regions, from the spinal cord to the cerebral cortex, and in many animal species, ranging from invertebrates to humans, has demonstrated a reliable capacity for chemical synapses to undergo lasting changes in efficacy in response to a variety of induction protocols. In addition to their physiological relevance, long-term potentiation and depression may have important clinical applications. A growing insight into the molecular mechanisms underlying these processes, and technological advances in non-invasive manipulation of brain activity, now puts us at the threshold of harnessing long-term potentiation and depression and other forms of synaptic, cellular and circuit plasticity to manipulate synaptic strength in the human nervous system. Drugs may be used to erase or treat pathological synaptic states and non-invasive stimulation devices may be used to artificially induce synaptic plasticity to ameliorate conditions arising from disrupted synaptic drive. These approaches hold promise for the treatment of a variety of neurological conditions, including neuropathic pain, epilepsy, depression, amblyopia, tinnitus and stroke. Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2011-06 /pmc/articles/PMC3118435/ /pubmed/21779718 http://dx.doi.org/10.1590/S1807-59322011001300002 Text en Copyright © 2011 Hospital das Clínicas da FMUSP http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Editorial Bliss, Timothy V.P. Cooke, Sam F Long-term potentiation and long-term depression: a clinical perspective |
title | Long-term potentiation and long-term depression: a clinical perspective |
title_full | Long-term potentiation and long-term depression: a clinical perspective |
title_fullStr | Long-term potentiation and long-term depression: a clinical perspective |
title_full_unstemmed | Long-term potentiation and long-term depression: a clinical perspective |
title_short | Long-term potentiation and long-term depression: a clinical perspective |
title_sort | long-term potentiation and long-term depression: a clinical perspective |
topic | Editorial |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118435/ https://www.ncbi.nlm.nih.gov/pubmed/21779718 http://dx.doi.org/10.1590/S1807-59322011001300002 |
work_keys_str_mv | AT blisstimothyvp longtermpotentiationandlongtermdepressionaclinicalperspective AT cookesamf longtermpotentiationandlongtermdepressionaclinicalperspective |