Cargando…
Non-Neoplastic and Neoplastic Pleural Endpoints Following Fiber Exposure
Exposure to asbestos fibers is associated with non-neoplastic pleural diseases including plaques, fibrosis, and benign effusions, as well as with diffuse malignant pleural mesothelioma. Translocation and retention of fibers are fundamental processes in understanding the interactions between the dose...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118521/ https://www.ncbi.nlm.nih.gov/pubmed/21534088 http://dx.doi.org/10.1080/10937404.2011.556049 |
_version_ | 1782206483346227200 |
---|---|
author | Broaddus, V. Courtney Everitt, Jeffrey I. Black, Brad Kane, Agnes B. |
author_facet | Broaddus, V. Courtney Everitt, Jeffrey I. Black, Brad Kane, Agnes B. |
author_sort | Broaddus, V. Courtney |
collection | PubMed |
description | Exposure to asbestos fibers is associated with non-neoplastic pleural diseases including plaques, fibrosis, and benign effusions, as well as with diffuse malignant pleural mesothelioma. Translocation and retention of fibers are fundamental processes in understanding the interactions between the dose and dimensions of fibers retained at this anatomic site and the subsequent pathological reactions. The initial interaction of fibers with target cells in the pleura has been studied in cellular models in vitro and in experimental studies in vivo. The proposed biological mechanisms responsible for non-neoplastic and neoplastic pleural diseases and the physical and chemical properties of asbestos fibers relevant to these mechanisms are critically reviewed. Understanding mechanisms of asbestos fiber toxicity may help us anticipate the problems from future exposures both to asbestos and to novel fibrous materials such as nanotubes. Gaps in our understanding have been outlined as guides for future research. |
format | Online Article Text |
id | pubmed-3118521 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-31185212011-07-07 Non-Neoplastic and Neoplastic Pleural Endpoints Following Fiber Exposure Broaddus, V. Courtney Everitt, Jeffrey I. Black, Brad Kane, Agnes B. J Toxicol Environ Health B Crit Rev Research Article Exposure to asbestos fibers is associated with non-neoplastic pleural diseases including plaques, fibrosis, and benign effusions, as well as with diffuse malignant pleural mesothelioma. Translocation and retention of fibers are fundamental processes in understanding the interactions between the dose and dimensions of fibers retained at this anatomic site and the subsequent pathological reactions. The initial interaction of fibers with target cells in the pleura has been studied in cellular models in vitro and in experimental studies in vivo. The proposed biological mechanisms responsible for non-neoplastic and neoplastic pleural diseases and the physical and chemical properties of asbestos fibers relevant to these mechanisms are critically reviewed. Understanding mechanisms of asbestos fiber toxicity may help us anticipate the problems from future exposures both to asbestos and to novel fibrous materials such as nanotubes. Gaps in our understanding have been outlined as guides for future research. Taylor & Francis 2011-06-02 2011 /pmc/articles/PMC3118521/ /pubmed/21534088 http://dx.doi.org/10.1080/10937404.2011.556049 Text en © 2011 Taylor & Francis http://www.informaworld.com/mpp/uploads/iopenaccess_tcs.pdf This is an open access article distributed under the Supplemental Terms and Conditions for iOpenAccess articles published in Taylor & Francis journals (http://www.informaworld.com/mpp/uploads/iopenaccess_tcs.pdf) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Broaddus, V. Courtney Everitt, Jeffrey I. Black, Brad Kane, Agnes B. Non-Neoplastic and Neoplastic Pleural Endpoints Following Fiber Exposure |
title | Non-Neoplastic and Neoplastic Pleural Endpoints Following Fiber Exposure |
title_full | Non-Neoplastic and Neoplastic Pleural Endpoints Following Fiber Exposure |
title_fullStr | Non-Neoplastic and Neoplastic Pleural Endpoints Following Fiber Exposure |
title_full_unstemmed | Non-Neoplastic and Neoplastic Pleural Endpoints Following Fiber Exposure |
title_short | Non-Neoplastic and Neoplastic Pleural Endpoints Following Fiber Exposure |
title_sort | non-neoplastic and neoplastic pleural endpoints following fiber exposure |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118521/ https://www.ncbi.nlm.nih.gov/pubmed/21534088 http://dx.doi.org/10.1080/10937404.2011.556049 |
work_keys_str_mv | AT broaddusvcourtney nonneoplasticandneoplasticpleuralendpointsfollowingfiberexposure AT everittjeffreyi nonneoplasticandneoplasticpleuralendpointsfollowingfiberexposure AT blackbrad nonneoplasticandneoplasticpleuralendpointsfollowingfiberexposure AT kaneagnesb nonneoplasticandneoplasticpleuralendpointsfollowingfiberexposure |