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Non-Neoplastic and Neoplastic Pleural Endpoints Following Fiber Exposure

Exposure to asbestos fibers is associated with non-neoplastic pleural diseases including plaques, fibrosis, and benign effusions, as well as with diffuse malignant pleural mesothelioma. Translocation and retention of fibers are fundamental processes in understanding the interactions between the dose...

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Detalles Bibliográficos
Autores principales: Broaddus, V. Courtney, Everitt, Jeffrey I., Black, Brad, Kane, Agnes B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118521/
https://www.ncbi.nlm.nih.gov/pubmed/21534088
http://dx.doi.org/10.1080/10937404.2011.556049
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author Broaddus, V. Courtney
Everitt, Jeffrey I.
Black, Brad
Kane, Agnes B.
author_facet Broaddus, V. Courtney
Everitt, Jeffrey I.
Black, Brad
Kane, Agnes B.
author_sort Broaddus, V. Courtney
collection PubMed
description Exposure to asbestos fibers is associated with non-neoplastic pleural diseases including plaques, fibrosis, and benign effusions, as well as with diffuse malignant pleural mesothelioma. Translocation and retention of fibers are fundamental processes in understanding the interactions between the dose and dimensions of fibers retained at this anatomic site and the subsequent pathological reactions. The initial interaction of fibers with target cells in the pleura has been studied in cellular models in vitro and in experimental studies in vivo. The proposed biological mechanisms responsible for non-neoplastic and neoplastic pleural diseases and the physical and chemical properties of asbestos fibers relevant to these mechanisms are critically reviewed. Understanding mechanisms of asbestos fiber toxicity may help us anticipate the problems from future exposures both to asbestos and to novel fibrous materials such as nanotubes. Gaps in our understanding have been outlined as guides for future research.
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spelling pubmed-31185212011-07-07 Non-Neoplastic and Neoplastic Pleural Endpoints Following Fiber Exposure Broaddus, V. Courtney Everitt, Jeffrey I. Black, Brad Kane, Agnes B. J Toxicol Environ Health B Crit Rev Research Article Exposure to asbestos fibers is associated with non-neoplastic pleural diseases including plaques, fibrosis, and benign effusions, as well as with diffuse malignant pleural mesothelioma. Translocation and retention of fibers are fundamental processes in understanding the interactions between the dose and dimensions of fibers retained at this anatomic site and the subsequent pathological reactions. The initial interaction of fibers with target cells in the pleura has been studied in cellular models in vitro and in experimental studies in vivo. The proposed biological mechanisms responsible for non-neoplastic and neoplastic pleural diseases and the physical and chemical properties of asbestos fibers relevant to these mechanisms are critically reviewed. Understanding mechanisms of asbestos fiber toxicity may help us anticipate the problems from future exposures both to asbestos and to novel fibrous materials such as nanotubes. Gaps in our understanding have been outlined as guides for future research. Taylor & Francis 2011-06-02 2011 /pmc/articles/PMC3118521/ /pubmed/21534088 http://dx.doi.org/10.1080/10937404.2011.556049 Text en © 2011 Taylor & Francis http://www.informaworld.com/mpp/uploads/iopenaccess_tcs.pdf This is an open access article distributed under the Supplemental Terms and Conditions for iOpenAccess articles published in Taylor & Francis journals (http://www.informaworld.com/mpp/uploads/iopenaccess_tcs.pdf) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Broaddus, V. Courtney
Everitt, Jeffrey I.
Black, Brad
Kane, Agnes B.
Non-Neoplastic and Neoplastic Pleural Endpoints Following Fiber Exposure
title Non-Neoplastic and Neoplastic Pleural Endpoints Following Fiber Exposure
title_full Non-Neoplastic and Neoplastic Pleural Endpoints Following Fiber Exposure
title_fullStr Non-Neoplastic and Neoplastic Pleural Endpoints Following Fiber Exposure
title_full_unstemmed Non-Neoplastic and Neoplastic Pleural Endpoints Following Fiber Exposure
title_short Non-Neoplastic and Neoplastic Pleural Endpoints Following Fiber Exposure
title_sort non-neoplastic and neoplastic pleural endpoints following fiber exposure
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118521/
https://www.ncbi.nlm.nih.gov/pubmed/21534088
http://dx.doi.org/10.1080/10937404.2011.556049
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