In Vitro Antiplasmodial Activity of Sesquiterpene Lactones from Ambrosia tenuifolia

The in vitro antiplasmodial activity of Ambrosia tenuifolia organic extract and its isolated sesquiterpene lactones, psilostachyin and peruvin, has been evaluated against Plasmodium falciparum F32 and W2 strains. The cytotoxicity of both compounds was determined on lymphoid cells, and their correspo...

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Autores principales: Sülsen, V., Gutierrez Yappu, D., Laurella, L., Anesini, C., Gimenez Turba, A., Martino, V., Muschietti, L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118529/
https://www.ncbi.nlm.nih.gov/pubmed/21716685
http://dx.doi.org/10.1155/2011/352938
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author Sülsen, V.
Gutierrez Yappu, D.
Laurella, L.
Anesini, C.
Gimenez Turba, A.
Martino, V.
Muschietti, L.
author_facet Sülsen, V.
Gutierrez Yappu, D.
Laurella, L.
Anesini, C.
Gimenez Turba, A.
Martino, V.
Muschietti, L.
author_sort Sülsen, V.
collection PubMed
description The in vitro antiplasmodial activity of Ambrosia tenuifolia organic extract and its isolated sesquiterpene lactones, psilostachyin and peruvin, has been evaluated against Plasmodium falciparum F32 and W2 strains. The cytotoxicity of both compounds was determined on lymphoid cells, and their corresponding selectivity indexes (SIs) were calculated. Peruvin was the most active compound on F32 strain of P. falciparum with a 50% inhibitory concentration value (IC(50)) of 0.3 μg/mL (1.1 μM) whereas psilostachyin showed activity on both strains (IC(50) = 0.6 (2.1 μM) and 1.8 μg/mL (6.4 μM)). Fifty percent cytotoxic concentration (CC(50)) values (48 h) were 6.8 μg/mL (24.3 μM) and 10.0 μg/mL (37.9 μM) for psilostachyin and peruvin, respectively.
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spelling pubmed-31185292011-06-28 In Vitro Antiplasmodial Activity of Sesquiterpene Lactones from Ambrosia tenuifolia Sülsen, V. Gutierrez Yappu, D. Laurella, L. Anesini, C. Gimenez Turba, A. Martino, V. Muschietti, L. Evid Based Complement Alternat Med Research Article The in vitro antiplasmodial activity of Ambrosia tenuifolia organic extract and its isolated sesquiterpene lactones, psilostachyin and peruvin, has been evaluated against Plasmodium falciparum F32 and W2 strains. The cytotoxicity of both compounds was determined on lymphoid cells, and their corresponding selectivity indexes (SIs) were calculated. Peruvin was the most active compound on F32 strain of P. falciparum with a 50% inhibitory concentration value (IC(50)) of 0.3 μg/mL (1.1 μM) whereas psilostachyin showed activity on both strains (IC(50) = 0.6 (2.1 μM) and 1.8 μg/mL (6.4 μM)). Fifty percent cytotoxic concentration (CC(50)) values (48 h) were 6.8 μg/mL (24.3 μM) and 10.0 μg/mL (37.9 μM) for psilostachyin and peruvin, respectively. Hindawi Publishing Corporation 2011 2011-05-25 /pmc/articles/PMC3118529/ /pubmed/21716685 http://dx.doi.org/10.1155/2011/352938 Text en Copyright © 2011 V. Sülsen et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Sülsen, V.
Gutierrez Yappu, D.
Laurella, L.
Anesini, C.
Gimenez Turba, A.
Martino, V.
Muschietti, L.
In Vitro Antiplasmodial Activity of Sesquiterpene Lactones from Ambrosia tenuifolia
title In Vitro Antiplasmodial Activity of Sesquiterpene Lactones from Ambrosia tenuifolia
title_full In Vitro Antiplasmodial Activity of Sesquiterpene Lactones from Ambrosia tenuifolia
title_fullStr In Vitro Antiplasmodial Activity of Sesquiterpene Lactones from Ambrosia tenuifolia
title_full_unstemmed In Vitro Antiplasmodial Activity of Sesquiterpene Lactones from Ambrosia tenuifolia
title_short In Vitro Antiplasmodial Activity of Sesquiterpene Lactones from Ambrosia tenuifolia
title_sort in vitro antiplasmodial activity of sesquiterpene lactones from ambrosia tenuifolia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118529/
https://www.ncbi.nlm.nih.gov/pubmed/21716685
http://dx.doi.org/10.1155/2011/352938
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