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Inflammatory Mechanisms of Organ Crosstalk during Ischemic Acute Kidney Injury
Acute kidney injury (AKI) is a common complication during inpatient hospitalization, and clinical outcomes remain poor despite advancements in renal replacement therapy. AKI in the setting of multiple organ failure (MOF) remains a formidable challenge to clinicians and incurs an unacceptably high mo...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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SAGE-Hindawi Access to Research
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118535/ https://www.ncbi.nlm.nih.gov/pubmed/21826270 http://dx.doi.org/10.4061/2012/505197 |
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author | White, Laura E. Hassoun, Heitham T. |
author_facet | White, Laura E. Hassoun, Heitham T. |
author_sort | White, Laura E. |
collection | PubMed |
description | Acute kidney injury (AKI) is a common complication during inpatient hospitalization, and clinical outcomes remain poor despite advancements in renal replacement therapy. AKI in the setting of multiple organ failure (MOF) remains a formidable challenge to clinicians and incurs an unacceptably high mortality rate. Kidney ischemia-reperfusion injury (IRI) incites a proinflammatory cascade and releases cellular and soluble mediators with systemic implications for remote organ injury. Evidence from preclinical models cites mechanisms of organ crosstalk during ischemic AKI including the expression of cellular adhesion molecules, lymphocyte trafficking, release of proinflammatory cytokines and chemokines, and modification of the host innate and adaptive immune response systems. In this paper, the influence of kidney IRI on systemic inflammation and distant organ injury will be examined. Recent experimental data and evolving concepts of organ crosstalk during ischemic AKI will also be discussed in detail. |
format | Online Article Text |
id | pubmed-3118535 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | SAGE-Hindawi Access to Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-31185352011-08-08 Inflammatory Mechanisms of Organ Crosstalk during Ischemic Acute Kidney Injury White, Laura E. Hassoun, Heitham T. Int J Nephrol Review Article Acute kidney injury (AKI) is a common complication during inpatient hospitalization, and clinical outcomes remain poor despite advancements in renal replacement therapy. AKI in the setting of multiple organ failure (MOF) remains a formidable challenge to clinicians and incurs an unacceptably high mortality rate. Kidney ischemia-reperfusion injury (IRI) incites a proinflammatory cascade and releases cellular and soluble mediators with systemic implications for remote organ injury. Evidence from preclinical models cites mechanisms of organ crosstalk during ischemic AKI including the expression of cellular adhesion molecules, lymphocyte trafficking, release of proinflammatory cytokines and chemokines, and modification of the host innate and adaptive immune response systems. In this paper, the influence of kidney IRI on systemic inflammation and distant organ injury will be examined. Recent experimental data and evolving concepts of organ crosstalk during ischemic AKI will also be discussed in detail. SAGE-Hindawi Access to Research 2011-06-09 /pmc/articles/PMC3118535/ /pubmed/21826270 http://dx.doi.org/10.4061/2012/505197 Text en Copyright © 2012 L. E. White and H. T. Hassoun. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article White, Laura E. Hassoun, Heitham T. Inflammatory Mechanisms of Organ Crosstalk during Ischemic Acute Kidney Injury |
title | Inflammatory Mechanisms of Organ Crosstalk during Ischemic Acute Kidney Injury |
title_full | Inflammatory Mechanisms of Organ Crosstalk during Ischemic Acute Kidney Injury |
title_fullStr | Inflammatory Mechanisms of Organ Crosstalk during Ischemic Acute Kidney Injury |
title_full_unstemmed | Inflammatory Mechanisms of Organ Crosstalk during Ischemic Acute Kidney Injury |
title_short | Inflammatory Mechanisms of Organ Crosstalk during Ischemic Acute Kidney Injury |
title_sort | inflammatory mechanisms of organ crosstalk during ischemic acute kidney injury |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118535/ https://www.ncbi.nlm.nih.gov/pubmed/21826270 http://dx.doi.org/10.4061/2012/505197 |
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