Biopsy-Proven Acute Tubular Necrosis due to Vancomycin Toxicity

Vancomycin (VAN) has been associated with acute kidney injury (AKI) since it has been put into clinical use in the 1950's. Early reports of AKI were likely linked to the impurities of the VAN preparation. With the advent of the more purified forms of VAN, the incidence of AKI related to VAN wer...

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Autores principales: Shah-Khan, Farheen, Scheetz, Marc H., Ghossein, Cybele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2011
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118644/
https://www.ncbi.nlm.nih.gov/pubmed/21716699
http://dx.doi.org/10.4061/2011/436856
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author Shah-Khan, Farheen
Scheetz, Marc H.
Ghossein, Cybele
author_facet Shah-Khan, Farheen
Scheetz, Marc H.
Ghossein, Cybele
author_sort Shah-Khan, Farheen
collection PubMed
description Vancomycin (VAN) has been associated with acute kidney injury (AKI) since it has been put into clinical use in the 1950's. Early reports of AKI were likely linked to the impurities of the VAN preparation. With the advent of the more purified forms of VAN, the incidence of AKI related to VAN were limited to acute interstitial nephritis (AIN) or as a potentiating agent to other nephrotoxins such as Aminoglycosides. VAN as the sole etiologic factor for nephrotoxic acute tubular necrosis (ATN) has not been described. Here, we report a case of biopsy-proven ATN resulting from VAN.
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spelling pubmed-31186442011-06-28 Biopsy-Proven Acute Tubular Necrosis due to Vancomycin Toxicity Shah-Khan, Farheen Scheetz, Marc H. Ghossein, Cybele Int J Nephrol Case Report Vancomycin (VAN) has been associated with acute kidney injury (AKI) since it has been put into clinical use in the 1950's. Early reports of AKI were likely linked to the impurities of the VAN preparation. With the advent of the more purified forms of VAN, the incidence of AKI related to VAN were limited to acute interstitial nephritis (AIN) or as a potentiating agent to other nephrotoxins such as Aminoglycosides. VAN as the sole etiologic factor for nephrotoxic acute tubular necrosis (ATN) has not been described. Here, we report a case of biopsy-proven ATN resulting from VAN. SAGE-Hindawi Access to Research 2011-06-16 /pmc/articles/PMC3118644/ /pubmed/21716699 http://dx.doi.org/10.4061/2011/436856 Text en Copyright © 2011 Farheen Shah-Khan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Shah-Khan, Farheen
Scheetz, Marc H.
Ghossein, Cybele
Biopsy-Proven Acute Tubular Necrosis due to Vancomycin Toxicity
title Biopsy-Proven Acute Tubular Necrosis due to Vancomycin Toxicity
title_full Biopsy-Proven Acute Tubular Necrosis due to Vancomycin Toxicity
title_fullStr Biopsy-Proven Acute Tubular Necrosis due to Vancomycin Toxicity
title_full_unstemmed Biopsy-Proven Acute Tubular Necrosis due to Vancomycin Toxicity
title_short Biopsy-Proven Acute Tubular Necrosis due to Vancomycin Toxicity
title_sort biopsy-proven acute tubular necrosis due to vancomycin toxicity
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118644/
https://www.ncbi.nlm.nih.gov/pubmed/21716699
http://dx.doi.org/10.4061/2011/436856
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AT scheetzmarch biopsyprovenacutetubularnecrosisduetovancomycintoxicity
AT ghosseincybele biopsyprovenacutetubularnecrosisduetovancomycintoxicity

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