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Effects of the Topical Application of Hydroalcoholic Leaf Extract of Oncidium flexuosum Sims. (Orchidaceae) and Microcurrent on the Healing of Wounds Surgically Induced in Wistar Rats
This study evaluated the wound healing activity of hydroalcoholic leaf extract of Oncidium flexuosum Sims. (Orchidaceae), an important native plant of Brazil, combined or not with microcurrent stimulation. Wistar rats were randomly divided into four groups of nine animals: control (C), topical appli...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118730/ https://www.ncbi.nlm.nih.gov/pubmed/21716707 http://dx.doi.org/10.1155/2011/950347 |
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author | de Gaspi, Fernanda Oliveira de G. Foglio, Mary Ann de Carvalho, João Ernesto Santos, Gláucia Maria T. Testa, Milene Passarini, José Roberto de Moraes, Cristiano Pedroso Esquisatto, Marcelo A. Marreto Mendonça, Josué S. Mendonça, Fernanda A. Sampaio |
author_facet | de Gaspi, Fernanda Oliveira de G. Foglio, Mary Ann de Carvalho, João Ernesto Santos, Gláucia Maria T. Testa, Milene Passarini, José Roberto de Moraes, Cristiano Pedroso Esquisatto, Marcelo A. Marreto Mendonça, Josué S. Mendonça, Fernanda A. Sampaio |
author_sort | de Gaspi, Fernanda Oliveira de G. |
collection | PubMed |
description | This study evaluated the wound healing activity of hydroalcoholic leaf extract of Oncidium flexuosum Sims. (Orchidaceae), an important native plant of Brazil, combined or not with microcurrent stimulation. Wistar rats were randomly divided into four groups of nine animals: control (C), topical application of the extract (OF), treated with a microcurrent (10 μA/2 min) (MC), and topical application of the extract plus microcurrent (OF + MC). Tissue samples were obtained 2, 6, and 10 days after injury and submitted to structural and morphometric analysis. The simultaneous application of OF + MC was found to be highly effective in terms of the parameters analyzed (P < .05), with positive effects on the area of newly formed tissue, number of fibroblasts, number of newly formed blood vessels, and epithelial thickness. Morphometric data confirmed the structural findings. The O. flexuosum leaf extract contains active compounds that speed the healing process, especially when applied simultaneously with microcurrent stimulation. |
format | Online Article Text |
id | pubmed-3118730 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-31187302011-06-28 Effects of the Topical Application of Hydroalcoholic Leaf Extract of Oncidium flexuosum Sims. (Orchidaceae) and Microcurrent on the Healing of Wounds Surgically Induced in Wistar Rats de Gaspi, Fernanda Oliveira de G. Foglio, Mary Ann de Carvalho, João Ernesto Santos, Gláucia Maria T. Testa, Milene Passarini, José Roberto de Moraes, Cristiano Pedroso Esquisatto, Marcelo A. Marreto Mendonça, Josué S. Mendonça, Fernanda A. Sampaio Evid Based Complement Alternat Med Research Article This study evaluated the wound healing activity of hydroalcoholic leaf extract of Oncidium flexuosum Sims. (Orchidaceae), an important native plant of Brazil, combined or not with microcurrent stimulation. Wistar rats were randomly divided into four groups of nine animals: control (C), topical application of the extract (OF), treated with a microcurrent (10 μA/2 min) (MC), and topical application of the extract plus microcurrent (OF + MC). Tissue samples were obtained 2, 6, and 10 days after injury and submitted to structural and morphometric analysis. The simultaneous application of OF + MC was found to be highly effective in terms of the parameters analyzed (P < .05), with positive effects on the area of newly formed tissue, number of fibroblasts, number of newly formed blood vessels, and epithelial thickness. Morphometric data confirmed the structural findings. The O. flexuosum leaf extract contains active compounds that speed the healing process, especially when applied simultaneously with microcurrent stimulation. Hindawi Publishing Corporation 2011 2011-06-09 /pmc/articles/PMC3118730/ /pubmed/21716707 http://dx.doi.org/10.1155/2011/950347 Text en Copyright © 2011 Fernanda Oliveira de G. de Gaspi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article de Gaspi, Fernanda Oliveira de G. Foglio, Mary Ann de Carvalho, João Ernesto Santos, Gláucia Maria T. Testa, Milene Passarini, José Roberto de Moraes, Cristiano Pedroso Esquisatto, Marcelo A. Marreto Mendonça, Josué S. Mendonça, Fernanda A. Sampaio Effects of the Topical Application of Hydroalcoholic Leaf Extract of Oncidium flexuosum Sims. (Orchidaceae) and Microcurrent on the Healing of Wounds Surgically Induced in Wistar Rats |
title | Effects of the Topical Application of Hydroalcoholic Leaf Extract of Oncidium flexuosum Sims. (Orchidaceae) and Microcurrent on the Healing of Wounds Surgically Induced in Wistar Rats |
title_full | Effects of the Topical Application of Hydroalcoholic Leaf Extract of Oncidium flexuosum Sims. (Orchidaceae) and Microcurrent on the Healing of Wounds Surgically Induced in Wistar Rats |
title_fullStr | Effects of the Topical Application of Hydroalcoholic Leaf Extract of Oncidium flexuosum Sims. (Orchidaceae) and Microcurrent on the Healing of Wounds Surgically Induced in Wistar Rats |
title_full_unstemmed | Effects of the Topical Application of Hydroalcoholic Leaf Extract of Oncidium flexuosum Sims. (Orchidaceae) and Microcurrent on the Healing of Wounds Surgically Induced in Wistar Rats |
title_short | Effects of the Topical Application of Hydroalcoholic Leaf Extract of Oncidium flexuosum Sims. (Orchidaceae) and Microcurrent on the Healing of Wounds Surgically Induced in Wistar Rats |
title_sort | effects of the topical application of hydroalcoholic leaf extract of oncidium flexuosum sims. (orchidaceae) and microcurrent on the healing of wounds surgically induced in wistar rats |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118730/ https://www.ncbi.nlm.nih.gov/pubmed/21716707 http://dx.doi.org/10.1155/2011/950347 |
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