Overexpression of eIF-5A2 in mice causes accelerated organismal aging by increasing chromosome instability

BACKGROUND: Amplification of 3q26 is one of the most frequent genetic alterations in many human malignancies. Recently, we isolated a novel oncogene eIF-5A2 within the 3q26 region. Functional study has demonstrated the oncogenic role of eIF-5A2 in the initiation and progression of human cancers. In...

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Detalles Bibliográficos
Autores principales: Chen, Muhan, Huang, Jian-Dong, Deng, Hong Kui, Dong, Suisui, Deng, Wen, Tsang, Sze Lan, Huen, Michael SY, Chen, Leilei, Zan, Tong, Zhu, Gui-Xia, Guan, Xin-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118894/
https://www.ncbi.nlm.nih.gov/pubmed/21612665
http://dx.doi.org/10.1186/1471-2407-11-199

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