Targeting EGFR in Triple Negative Breast Cancer

Our preliminary data show that erlotinib inhibits Triple-negative breast cancer (TNBC) in a xenograft model. However, inhibition of metastasis by erlotinib is accompanied by nonspecific effects because erlotinib can inhibit other kinases; thus, more direct targets that regulate TNBC metastasis need...

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Detalles Bibliográficos
Autores principales: Ueno, Naoto T., Zhang, Dongwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2011
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119395/
https://www.ncbi.nlm.nih.gov/pubmed/21716849
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author Ueno, Naoto T.
Zhang, Dongwei
author_facet Ueno, Naoto T.
Zhang, Dongwei
author_sort Ueno, Naoto T.
collection PubMed
description Our preliminary data show that erlotinib inhibits Triple-negative breast cancer (TNBC) in a xenograft model. However, inhibition of metastasis by erlotinib is accompanied by nonspecific effects because erlotinib can inhibit other kinases; thus, more direct targets that regulate TNBC metastasis need to be identified to improve its therapeutic efficacy.
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spelling pubmed-31193952011-06-28 Targeting EGFR in Triple Negative Breast Cancer Ueno, Naoto T. Zhang, Dongwei J Cancer Short Report Our preliminary data show that erlotinib inhibits Triple-negative breast cancer (TNBC) in a xenograft model. However, inhibition of metastasis by erlotinib is accompanied by nonspecific effects because erlotinib can inhibit other kinases; thus, more direct targets that regulate TNBC metastasis need to be identified to improve its therapeutic efficacy. Ivyspring International Publisher 2011-05-28 /pmc/articles/PMC3119395/ /pubmed/21716849 Text en © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, non-commercial use, provided that the article is in whole, unmodified, and properly cited.
spellingShingle Short Report
Ueno, Naoto T.
Zhang, Dongwei
Targeting EGFR in Triple Negative Breast Cancer
title Targeting EGFR in Triple Negative Breast Cancer
title_full Targeting EGFR in Triple Negative Breast Cancer
title_fullStr Targeting EGFR in Triple Negative Breast Cancer
title_full_unstemmed Targeting EGFR in Triple Negative Breast Cancer
title_short Targeting EGFR in Triple Negative Breast Cancer
title_sort targeting egfr in triple negative breast cancer
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119395/
https://www.ncbi.nlm.nih.gov/pubmed/21716849
work_keys_str_mv AT uenonaotot targetingegfrintriplenegativebreastcancer
AT zhangdongwei targetingegfrintriplenegativebreastcancer

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