Immunological Effects of Multikinase Inhibitors for Kidney Cancer: A Clue for Integration with Cellular Therapies?

The multikinase inhibitors Sunitinib and Sorafenib not only inhibit angiogenesis and tumor growth, but also have the potential of interacting with the function of the immune system. Presently available data seem to suggest that Sorafenib may exert immune suppressive effects, whilst the effects of Su...

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Autores principales: Porta, Camillo, Paglino, Chiara, Imarisio, Ilaria, Ganini, Carlo, Pedrazzoli, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119398/
https://www.ncbi.nlm.nih.gov/pubmed/21716852
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author Porta, Camillo
Paglino, Chiara
Imarisio, Ilaria
Ganini, Carlo
Pedrazzoli, Paolo
author_facet Porta, Camillo
Paglino, Chiara
Imarisio, Ilaria
Ganini, Carlo
Pedrazzoli, Paolo
author_sort Porta, Camillo
collection PubMed
description The multikinase inhibitors Sunitinib and Sorafenib not only inhibit angiogenesis and tumor growth, but also have the potential of interacting with the function of the immune system. Presently available data seem to suggest that Sorafenib may exert immune suppressive effects, whilst the effects of Sunitinib are not so clear, being immune stimulatory in the vast majority - but not all - the studies reported. Trials of combination of these multikinase inhibitors with different types of immune manipulation - and cellular therapies in particular - should be rationally designed taking into account all these complex effects, which ultimately deserve further insights.
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spelling pubmed-31193982011-06-28 Immunological Effects of Multikinase Inhibitors for Kidney Cancer: A Clue for Integration with Cellular Therapies? Porta, Camillo Paglino, Chiara Imarisio, Ilaria Ganini, Carlo Pedrazzoli, Paolo J Cancer Review The multikinase inhibitors Sunitinib and Sorafenib not only inhibit angiogenesis and tumor growth, but also have the potential of interacting with the function of the immune system. Presently available data seem to suggest that Sorafenib may exert immune suppressive effects, whilst the effects of Sunitinib are not so clear, being immune stimulatory in the vast majority - but not all - the studies reported. Trials of combination of these multikinase inhibitors with different types of immune manipulation - and cellular therapies in particular - should be rationally designed taking into account all these complex effects, which ultimately deserve further insights. Ivyspring International Publisher 2011-06-02 /pmc/articles/PMC3119398/ /pubmed/21716852 Text en © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.
spellingShingle Review
Porta, Camillo
Paglino, Chiara
Imarisio, Ilaria
Ganini, Carlo
Pedrazzoli, Paolo
Immunological Effects of Multikinase Inhibitors for Kidney Cancer: A Clue for Integration with Cellular Therapies?
title Immunological Effects of Multikinase Inhibitors for Kidney Cancer: A Clue for Integration with Cellular Therapies?
title_full Immunological Effects of Multikinase Inhibitors for Kidney Cancer: A Clue for Integration with Cellular Therapies?
title_fullStr Immunological Effects of Multikinase Inhibitors for Kidney Cancer: A Clue for Integration with Cellular Therapies?
title_full_unstemmed Immunological Effects of Multikinase Inhibitors for Kidney Cancer: A Clue for Integration with Cellular Therapies?
title_short Immunological Effects of Multikinase Inhibitors for Kidney Cancer: A Clue for Integration with Cellular Therapies?
title_sort immunological effects of multikinase inhibitors for kidney cancer: a clue for integration with cellular therapies?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119398/
https://www.ncbi.nlm.nih.gov/pubmed/21716852
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