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Human Herpesvirus 8 Seropositivity Among Sexually Active Adults in Uganda
INTRODUCTION: Sexual transmission of human herpesvirus 8 (HHV8) has been implicated among homosexual men, but the evidence for sexual transmission among heterosexual individuals is controversial. We investigated the role of sexual transmission of HHV8 in a nationally representative sample in Uganda,...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119672/ https://www.ncbi.nlm.nih.gov/pubmed/21712983 http://dx.doi.org/10.1371/journal.pone.0021286 |
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author | Shebl, Fatma M. Dollard, Sheila C. Pfeiffer, Ruth M. Biryahwaho, Benon Amin, Minal M. Munuo, Stella S. Hladik, Wolfgang Parsons, Ruth Graubard, Barry I. Mbulaiteye, Sam M. |
author_facet | Shebl, Fatma M. Dollard, Sheila C. Pfeiffer, Ruth M. Biryahwaho, Benon Amin, Minal M. Munuo, Stella S. Hladik, Wolfgang Parsons, Ruth Graubard, Barry I. Mbulaiteye, Sam M. |
author_sort | Shebl, Fatma M. |
collection | PubMed |
description | INTRODUCTION: Sexual transmission of human herpesvirus 8 (HHV8) has been implicated among homosexual men, but the evidence for sexual transmission among heterosexual individuals is controversial. We investigated the role of sexual transmission of HHV8 in a nationally representative sample in Uganda, where HHV8 infection is endemic and transmitted mostly during childhood. MATERIALS AND METHODS: The study population was a subset of participants (n = 2681) from a population-based HIV/AIDS serobehavioral survey of adults aged 15–59 years conducted in 2004/2005. High risk for sexual transmission was assessed by questionnaire and serological testing for HIV and herpes simplex virus 2. Anti-HHV8 antibodies were measured using two enzyme immunoassays targeting synthetic peptides from the K8.1 and orf65 viral genes. The current study was restricted to 2288 sexually active adults. ORs and 95% CIs for HHV8 seropositivity were estimated by fitting logistic regression models with a random intercept using MPLUS and SAS software. RESULTS: The weighted prevalence of HHV8 seropositivity was 56.2%, based on 1302 seropositive individuals, and it increased significantly with age (P (trend)<0.0001). In analyses adjusting for age, sex, geography, education, and HIV status, HHV8 seropositivity was positively associated with reporting two versus one marital union (OR:1.52, 95% CI: 1.17–1.97) and each unit increase in the number of children born (OR: 1.04, 95% CI: 1.00–1.08), and was inversely associated with ever having used a condom (OR: 0.64, 95% CI: 0.45–0.89). HHV8 seropositivity was not associated with HIV (P = 0.660) or with herpes simplex virus 2 (P = 0.732) seropositivity. Other sexual variables, including lifetime number of sexual partners or having had at least one sexually transmitted disease, and socioeconomic variables were unrelated to HHV8 seropositivity. CONCLUSION: Our findings are compatible with the conclusion that sexual transmission of HHV8 in Uganda, if it occurs, is weak. |
format | Online Article Text |
id | pubmed-3119672 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-31196722011-06-27 Human Herpesvirus 8 Seropositivity Among Sexually Active Adults in Uganda Shebl, Fatma M. Dollard, Sheila C. Pfeiffer, Ruth M. Biryahwaho, Benon Amin, Minal M. Munuo, Stella S. Hladik, Wolfgang Parsons, Ruth Graubard, Barry I. Mbulaiteye, Sam M. PLoS One Research Article INTRODUCTION: Sexual transmission of human herpesvirus 8 (HHV8) has been implicated among homosexual men, but the evidence for sexual transmission among heterosexual individuals is controversial. We investigated the role of sexual transmission of HHV8 in a nationally representative sample in Uganda, where HHV8 infection is endemic and transmitted mostly during childhood. MATERIALS AND METHODS: The study population was a subset of participants (n = 2681) from a population-based HIV/AIDS serobehavioral survey of adults aged 15–59 years conducted in 2004/2005. High risk for sexual transmission was assessed by questionnaire and serological testing for HIV and herpes simplex virus 2. Anti-HHV8 antibodies were measured using two enzyme immunoassays targeting synthetic peptides from the K8.1 and orf65 viral genes. The current study was restricted to 2288 sexually active adults. ORs and 95% CIs for HHV8 seropositivity were estimated by fitting logistic regression models with a random intercept using MPLUS and SAS software. RESULTS: The weighted prevalence of HHV8 seropositivity was 56.2%, based on 1302 seropositive individuals, and it increased significantly with age (P (trend)<0.0001). In analyses adjusting for age, sex, geography, education, and HIV status, HHV8 seropositivity was positively associated with reporting two versus one marital union (OR:1.52, 95% CI: 1.17–1.97) and each unit increase in the number of children born (OR: 1.04, 95% CI: 1.00–1.08), and was inversely associated with ever having used a condom (OR: 0.64, 95% CI: 0.45–0.89). HHV8 seropositivity was not associated with HIV (P = 0.660) or with herpes simplex virus 2 (P = 0.732) seropositivity. Other sexual variables, including lifetime number of sexual partners or having had at least one sexually transmitted disease, and socioeconomic variables were unrelated to HHV8 seropositivity. CONCLUSION: Our findings are compatible with the conclusion that sexual transmission of HHV8 in Uganda, if it occurs, is weak. Public Library of Science 2011-06-21 /pmc/articles/PMC3119672/ /pubmed/21712983 http://dx.doi.org/10.1371/journal.pone.0021286 Text en This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. https://creativecommons.org/publicdomain/zero/1.0/ This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. |
spellingShingle | Research Article Shebl, Fatma M. Dollard, Sheila C. Pfeiffer, Ruth M. Biryahwaho, Benon Amin, Minal M. Munuo, Stella S. Hladik, Wolfgang Parsons, Ruth Graubard, Barry I. Mbulaiteye, Sam M. Human Herpesvirus 8 Seropositivity Among Sexually Active Adults in Uganda |
title | Human Herpesvirus 8 Seropositivity Among Sexually Active Adults in Uganda |
title_full | Human Herpesvirus 8 Seropositivity Among Sexually Active Adults in Uganda |
title_fullStr | Human Herpesvirus 8 Seropositivity Among Sexually Active Adults in Uganda |
title_full_unstemmed | Human Herpesvirus 8 Seropositivity Among Sexually Active Adults in Uganda |
title_short | Human Herpesvirus 8 Seropositivity Among Sexually Active Adults in Uganda |
title_sort | human herpesvirus 8 seropositivity among sexually active adults in uganda |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119672/ https://www.ncbi.nlm.nih.gov/pubmed/21712983 http://dx.doi.org/10.1371/journal.pone.0021286 |
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