Blockade of Gap Junction Hemichannel Suppresses Disease Progression in Mouse Models of Amyotrophic Lateral Sclerosis and Alzheimer's Disease

BACKGROUND: Glutamate released by activated microglia induces excitotoxic neuronal death, which likely contributes to non-cell autonomous neuronal death in neurodegenerative diseases, including amyotrophic lateral sclerosis and Alzheimer's disease. Although both blockade of glutamate receptors...

Descripción completa

Detalles Bibliográficos
Autores principales: Takeuchi, Hideyuki, Mizoguchi, Hiroyuki, Doi, Yukiko, Jin, Shijie, Noda, Mariko, Liang, Jianfeng, Li, Hua, Zhou, Yan, Mori, Rarami, Yasuoka, Satoko, Li, Endong, Parajuli, Bijay, Kawanokuchi, Jun, Sonobe, Yoshifumi, Sato, Jun, Yamanaka, Koji, Sobue, Gen, Mizuno, Tetsuya, Suzumura, Akio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119678/
https://www.ncbi.nlm.nih.gov/pubmed/21712989
http://dx.doi.org/10.1371/journal.pone.0021108

Ejemplares similares

Ejemplares similares