Identification of MicroRNAs Involved in Hypoxia- and Serum Deprivation-Induced Apoptosis in Mesenchymal Stem Cells

The use of bone marrow mesenchymal stem cell- (MSC) transplantation therapy for cardiac diseases is limited due to poor survival of implanted cells. MicroRNAs (miRNAs) have been reported to be involved in regulating almost all cellular processes, including apoptosis. In this study, we found that the...

Descripción completa

Detalles Bibliográficos
Autores principales: Nie, Yu, Han, Bian-Mei, Liu, Xue-Bin, Yang, Jin-Jing, Wang, Fang, Cong, Xiang-Feng, Chen, Xi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2011
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119848/
https://www.ncbi.nlm.nih.gov/pubmed/21698002
_version_ 1782206602180296704
author Nie, Yu
Han, Bian-Mei
Liu, Xue-Bin
Yang, Jin-Jing
Wang, Fang
Cong, Xiang-Feng
Chen, Xi
author_facet Nie, Yu
Han, Bian-Mei
Liu, Xue-Bin
Yang, Jin-Jing
Wang, Fang
Cong, Xiang-Feng
Chen, Xi
author_sort Nie, Yu
collection PubMed
description The use of bone marrow mesenchymal stem cell- (MSC) transplantation therapy for cardiac diseases is limited due to poor survival of implanted cells. MicroRNAs (miRNAs) have been reported to be involved in regulating almost all cellular processes, including apoptosis. In this study, we found that the miRNA profile was altered during apoptosis induced by hypoxia and serum deprivation (hypoxia/SD). We further revealed that over-expression of miR-21, miR-23a and miR-210 could promote the survival of MSCs exposed to hypoxia/SD. In contrast, down-regulation of miR-21, miR-23a and miR-503 aggravated apoptosis of MSCs. It was indicated that these miRNAs may play important roles during MSC apoptosis induced by hypoxia/SD.
format Online
Article
Text
id pubmed-3119848
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Ivyspring International Publisher
record_format MEDLINE/PubMed
spelling pubmed-31198482011-06-22 Identification of MicroRNAs Involved in Hypoxia- and Serum Deprivation-Induced Apoptosis in Mesenchymal Stem Cells Nie, Yu Han, Bian-Mei Liu, Xue-Bin Yang, Jin-Jing Wang, Fang Cong, Xiang-Feng Chen, Xi Int J Biol Sci Research Paper The use of bone marrow mesenchymal stem cell- (MSC) transplantation therapy for cardiac diseases is limited due to poor survival of implanted cells. MicroRNAs (miRNAs) have been reported to be involved in regulating almost all cellular processes, including apoptosis. In this study, we found that the miRNA profile was altered during apoptosis induced by hypoxia and serum deprivation (hypoxia/SD). We further revealed that over-expression of miR-21, miR-23a and miR-210 could promote the survival of MSCs exposed to hypoxia/SD. In contrast, down-regulation of miR-21, miR-23a and miR-503 aggravated apoptosis of MSCs. It was indicated that these miRNAs may play important roles during MSC apoptosis induced by hypoxia/SD. Ivyspring International Publisher 2011-06-09 /pmc/articles/PMC3119848/ /pubmed/21698002 Text en © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.
spellingShingle Research Paper
Nie, Yu
Han, Bian-Mei
Liu, Xue-Bin
Yang, Jin-Jing
Wang, Fang
Cong, Xiang-Feng
Chen, Xi
Identification of MicroRNAs Involved in Hypoxia- and Serum Deprivation-Induced Apoptosis in Mesenchymal Stem Cells
title Identification of MicroRNAs Involved in Hypoxia- and Serum Deprivation-Induced Apoptosis in Mesenchymal Stem Cells
title_full Identification of MicroRNAs Involved in Hypoxia- and Serum Deprivation-Induced Apoptosis in Mesenchymal Stem Cells
title_fullStr Identification of MicroRNAs Involved in Hypoxia- and Serum Deprivation-Induced Apoptosis in Mesenchymal Stem Cells
title_full_unstemmed Identification of MicroRNAs Involved in Hypoxia- and Serum Deprivation-Induced Apoptosis in Mesenchymal Stem Cells
title_short Identification of MicroRNAs Involved in Hypoxia- and Serum Deprivation-Induced Apoptosis in Mesenchymal Stem Cells
title_sort identification of micrornas involved in hypoxia- and serum deprivation-induced apoptosis in mesenchymal stem cells
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119848/
https://www.ncbi.nlm.nih.gov/pubmed/21698002
work_keys_str_mv AT nieyu identificationofmicrornasinvolvedinhypoxiaandserumdeprivationinducedapoptosisinmesenchymalstemcells
AT hanbianmei identificationofmicrornasinvolvedinhypoxiaandserumdeprivationinducedapoptosisinmesenchymalstemcells
AT liuxuebin identificationofmicrornasinvolvedinhypoxiaandserumdeprivationinducedapoptosisinmesenchymalstemcells
AT yangjinjing identificationofmicrornasinvolvedinhypoxiaandserumdeprivationinducedapoptosisinmesenchymalstemcells
AT wangfang identificationofmicrornasinvolvedinhypoxiaandserumdeprivationinducedapoptosisinmesenchymalstemcells
AT congxiangfeng identificationofmicrornasinvolvedinhypoxiaandserumdeprivationinducedapoptosisinmesenchymalstemcells
AT chenxi identificationofmicrornasinvolvedinhypoxiaandserumdeprivationinducedapoptosisinmesenchymalstemcells

Ejemplares similares