Unstable eigenmodes are possible drivers for cardiac arrhythmias

The well-organized contraction of each heartbeat is enabled by an electrical wave traversing and exciting the myocardium in a regular manner. Perturbations to this wave, referred to as arrhythmias, can lead to lethal fibrillation if not treated within minutes. One manner in which arrhythmias origina...

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Detalles Bibliográficos
Autores principales: Tveito, Aslak, Lines, Glenn, Skavhaug, Ola, Maleckar, Mary M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2011
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119886/
https://www.ncbi.nlm.nih.gov/pubmed/21571942
http://dx.doi.org/10.1098/rsif.2011.0152
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author Tveito, Aslak
Lines, Glenn
Skavhaug, Ola
Maleckar, Mary M.
author_facet Tveito, Aslak
Lines, Glenn
Skavhaug, Ola
Maleckar, Mary M.
author_sort Tveito, Aslak
collection PubMed
description The well-organized contraction of each heartbeat is enabled by an electrical wave traversing and exciting the myocardium in a regular manner. Perturbations to this wave, referred to as arrhythmias, can lead to lethal fibrillation if not treated within minutes. One manner in which arrhythmias originate is an ill-fated interaction of the regular electrical signal controlling the heartbeat, the sinus wave, with an ectopic stimulus. It is not fully understood how and when ectopic waves are generated. Based on mathematical models, we show that ectopic beats can be characterized in terms of unstable eigenmodes of the resting state.
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spelling pubmed-31198862011-07-05 Unstable eigenmodes are possible drivers for cardiac arrhythmias Tveito, Aslak Lines, Glenn Skavhaug, Ola Maleckar, Mary M. J R Soc Interface Reports The well-organized contraction of each heartbeat is enabled by an electrical wave traversing and exciting the myocardium in a regular manner. Perturbations to this wave, referred to as arrhythmias, can lead to lethal fibrillation if not treated within minutes. One manner in which arrhythmias originate is an ill-fated interaction of the regular electrical signal controlling the heartbeat, the sinus wave, with an ectopic stimulus. It is not fully understood how and when ectopic waves are generated. Based on mathematical models, we show that ectopic beats can be characterized in terms of unstable eigenmodes of the resting state. The Royal Society 2011-08-07 2011-05-13 /pmc/articles/PMC3119886/ /pubmed/21571942 http://dx.doi.org/10.1098/rsif.2011.0152 Text en This Journal is © 2011 The Royal Society http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reports
Tveito, Aslak
Lines, Glenn
Skavhaug, Ola
Maleckar, Mary M.
Unstable eigenmodes are possible drivers for cardiac arrhythmias
title Unstable eigenmodes are possible drivers for cardiac arrhythmias
title_full Unstable eigenmodes are possible drivers for cardiac arrhythmias
title_fullStr Unstable eigenmodes are possible drivers for cardiac arrhythmias
title_full_unstemmed Unstable eigenmodes are possible drivers for cardiac arrhythmias
title_short Unstable eigenmodes are possible drivers for cardiac arrhythmias
title_sort unstable eigenmodes are possible drivers for cardiac arrhythmias
topic Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119886/
https://www.ncbi.nlm.nih.gov/pubmed/21571942
http://dx.doi.org/10.1098/rsif.2011.0152
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