Pharmacogenetics: A Tool for Identifying Genetic Factors in Drug Dependence and Response to Treatment

Pharmacogenetics research looks at variations in the human genome and ways in which genetic factors might influence how individuals respond to drugs. The authors review basic principles of pharmacogenetics and cite findings from several gene-phenotype studies to illustrate possible associations betw...

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Detalles Bibliográficos
Autores principales: Mroziewicz, Margaret, Tyndale, Rachel F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Institute on Drug Abuse 2010
Materias:
Research Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120126/
https://www.ncbi.nlm.nih.gov/pubmed/22002450
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author Mroziewicz, Margaret
Tyndale, Rachel F.
author_facet Mroziewicz, Margaret
Tyndale, Rachel F.
author_sort Mroziewicz, Margaret
collection PubMed
description Pharmacogenetics research looks at variations in the human genome and ways in which genetic factors might influence how individuals respond to drugs. The authors review basic principles of pharmacogenetics and cite findings from several gene-phenotype studies to illustrate possible associations between genetic variants, drug-related behaviors, and risk for drug dependence. Some gene variants affect responses to one drug; others, to various drugs. Pharmacogenetics can inform medication development and personalized treatment strategies; challenges lie along the pathway to its general use in clinical practice.
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spelling pubmed-31201262011-06-22 Pharmacogenetics: A Tool for Identifying Genetic Factors in Drug Dependence and Response to Treatment Mroziewicz, Margaret Tyndale, Rachel F. Addict Sci Clin Pract Research Review Pharmacogenetics research looks at variations in the human genome and ways in which genetic factors might influence how individuals respond to drugs. The authors review basic principles of pharmacogenetics and cite findings from several gene-phenotype studies to illustrate possible associations between genetic variants, drug-related behaviors, and risk for drug dependence. Some gene variants affect responses to one drug; others, to various drugs. Pharmacogenetics can inform medication development and personalized treatment strategies; challenges lie along the pathway to its general use in clinical practice. National Institute on Drug Abuse 2010-12 /pmc/articles/PMC3120126/ /pubmed/22002450 Text en
spellingShingle Research Review
Mroziewicz, Margaret
Tyndale, Rachel F.
Pharmacogenetics: A Tool for Identifying Genetic Factors in Drug Dependence and Response to Treatment
title Pharmacogenetics: A Tool for Identifying Genetic Factors in Drug Dependence and Response to Treatment
title_full Pharmacogenetics: A Tool for Identifying Genetic Factors in Drug Dependence and Response to Treatment
title_fullStr Pharmacogenetics: A Tool for Identifying Genetic Factors in Drug Dependence and Response to Treatment
title_full_unstemmed Pharmacogenetics: A Tool for Identifying Genetic Factors in Drug Dependence and Response to Treatment
title_short Pharmacogenetics: A Tool for Identifying Genetic Factors in Drug Dependence and Response to Treatment
title_sort pharmacogenetics: a tool for identifying genetic factors in drug dependence and response to treatment
topic Research Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120126/
https://www.ncbi.nlm.nih.gov/pubmed/22002450
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