HIV-1 Tat: Its Dependence on Host Factors is Crystal Clear

HIV-1 transcription is regulated at the level of elongation by the viral Tat protein together with the cellular elongation factor P-TEFb, which is composed of cyclin T1 and Cdk9 subunits. The crystal structure of a Tat:P-TEFb complex (Tahirov, T.H.; Babayeva, N.D.; Varzavand, K.; Cooper, J.J.; Sedor...

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Detalles Bibliográficos
Autores principales: D’Orso, Iván, Frankel, Alan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2010
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120229/
https://www.ncbi.nlm.nih.gov/pubmed/21709748
http://dx.doi.org/10.3390/v2102226
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author D’Orso, Iván
Frankel, Alan D.
author_facet D’Orso, Iván
Frankel, Alan D.
author_sort D’Orso, Iván
collection PubMed
description HIV-1 transcription is regulated at the level of elongation by the viral Tat protein together with the cellular elongation factor P-TEFb, which is composed of cyclin T1 and Cdk9 subunits. The crystal structure of a Tat:P-TEFb complex (Tahirov, T.H.; Babayeva, N.D.; Varzavand, K.; Cooper, J.J.; Sedore, S.C.; and Price, D.H. Crystal structure of HIV-1 Tat complexed with human P-TEFb. Nature 2010, 465, 747–751.) reveals molecular details of Tat and its interactions that have eluded investigators for more than two decades and provides provocative insights into the mechanism of Tat activation.
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spelling pubmed-31202292011-06-22 HIV-1 Tat: Its Dependence on Host Factors is Crystal Clear D’Orso, Iván Frankel, Alan D. Viruses Commentary HIV-1 transcription is regulated at the level of elongation by the viral Tat protein together with the cellular elongation factor P-TEFb, which is composed of cyclin T1 and Cdk9 subunits. The crystal structure of a Tat:P-TEFb complex (Tahirov, T.H.; Babayeva, N.D.; Varzavand, K.; Cooper, J.J.; Sedore, S.C.; and Price, D.H. Crystal structure of HIV-1 Tat complexed with human P-TEFb. Nature 2010, 465, 747–751.) reveals molecular details of Tat and its interactions that have eluded investigators for more than two decades and provides provocative insights into the mechanism of Tat activation. Molecular Diversity Preservation International (MDPI) 2010-10-06 /pmc/articles/PMC3120229/ /pubmed/21709748 http://dx.doi.org/10.3390/v2102226 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Commentary
D’Orso, Iván
Frankel, Alan D.
HIV-1 Tat: Its Dependence on Host Factors is Crystal Clear
title HIV-1 Tat: Its Dependence on Host Factors is Crystal Clear
title_full HIV-1 Tat: Its Dependence on Host Factors is Crystal Clear
title_fullStr HIV-1 Tat: Its Dependence on Host Factors is Crystal Clear
title_full_unstemmed HIV-1 Tat: Its Dependence on Host Factors is Crystal Clear
title_short HIV-1 Tat: Its Dependence on Host Factors is Crystal Clear
title_sort hiv-1 tat: its dependence on host factors is crystal clear
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120229/
https://www.ncbi.nlm.nih.gov/pubmed/21709748
http://dx.doi.org/10.3390/v2102226
work_keys_str_mv AT dorsoivan hiv1tatitsdependenceonhostfactorsiscrystalclear
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