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Left ventricular structure and function in prediabetic adults: Relationship with insulin resistance

INTRODUCTION: Several studies have shown that ventricular dysfunction is increased in individuals with diabetes. Insulin resistance (IR) may precede type 2 diabetes, and is a pathogenic factor for it. Furthermore, IR has been shown to be an independent predictor of cardiovascular disease in diabetes...

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Autores principales: Sliem, Hamdy, Nasr, Gamela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications Pvt Ltd 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120268/
https://www.ncbi.nlm.nih.gov/pubmed/21716748
http://dx.doi.org/10.4103/0975-3583.78583
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author Sliem, Hamdy
Nasr, Gamela
author_facet Sliem, Hamdy
Nasr, Gamela
author_sort Sliem, Hamdy
collection PubMed
description INTRODUCTION: Several studies have shown that ventricular dysfunction is increased in individuals with diabetes. Insulin resistance (IR) may precede type 2 diabetes, and is a pathogenic factor for it. Furthermore, IR has been shown to be an independent predictor of cardiovascular disease in diabetes. Given that glucose intolerance and IR precede the development of overt diabetes, these factors would be associated with abnormal myocardial performance. AIM OF THE WORK: To evaluate the state of left ventricular structure and function in prediabetic adults in relation with IR. PATIENTS AND METHODS: A case—control study was performed. One hundred and twenty-one consecutive adults with prediabetes were enrolled for the study. Forty-two of the adults had IR (group A) and 79 had insulin sensitivity (group B). Forty-three healthy (with normal blood glucose) adults matched for age and gender were considered as a control group. All groups were subjected to full medical history and clinical examination and biochemical and echocardiographic studies. RESULTS: There were no statistically significant differences between the insulin-sensitive prediabetic group and the control group in all parameters of left ventricular structure and systolic and diastolic functions. Significant differences were observed between group A and control group in the parameters of left ventricular diastolic function (both isovolumetric relaxation time and E/A ratio). Regarding correlation between the parameters of diastolic function and different variables of IR prediabetic group, there was a statistically significant coefficient correlation with HOMA IR, waist circumference and triglycerides. No correlation was observed with fasting glucose, Hb A1c, body mass index, blood pressure (BP) and total lipids. CONCLUSION: In prediabetic adults, IR is associated with impaired left ventricular diastolic function, and this association appears to be independent of BP, ventricular geometry, glucose tolerance status, total plasma lipids and obesity.
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spelling pubmed-31202682011-06-28 Left ventricular structure and function in prediabetic adults: Relationship with insulin resistance Sliem, Hamdy Nasr, Gamela J Cardiovasc Dis Res Original Article INTRODUCTION: Several studies have shown that ventricular dysfunction is increased in individuals with diabetes. Insulin resistance (IR) may precede type 2 diabetes, and is a pathogenic factor for it. Furthermore, IR has been shown to be an independent predictor of cardiovascular disease in diabetes. Given that glucose intolerance and IR precede the development of overt diabetes, these factors would be associated with abnormal myocardial performance. AIM OF THE WORK: To evaluate the state of left ventricular structure and function in prediabetic adults in relation with IR. PATIENTS AND METHODS: A case—control study was performed. One hundred and twenty-one consecutive adults with prediabetes were enrolled for the study. Forty-two of the adults had IR (group A) and 79 had insulin sensitivity (group B). Forty-three healthy (with normal blood glucose) adults matched for age and gender were considered as a control group. All groups were subjected to full medical history and clinical examination and biochemical and echocardiographic studies. RESULTS: There were no statistically significant differences between the insulin-sensitive prediabetic group and the control group in all parameters of left ventricular structure and systolic and diastolic functions. Significant differences were observed between group A and control group in the parameters of left ventricular diastolic function (both isovolumetric relaxation time and E/A ratio). Regarding correlation between the parameters of diastolic function and different variables of IR prediabetic group, there was a statistically significant coefficient correlation with HOMA IR, waist circumference and triglycerides. No correlation was observed with fasting glucose, Hb A1c, body mass index, blood pressure (BP) and total lipids. CONCLUSION: In prediabetic adults, IR is associated with impaired left ventricular diastolic function, and this association appears to be independent of BP, ventricular geometry, glucose tolerance status, total plasma lipids and obesity. Medknow Publications Pvt Ltd 2011 /pmc/articles/PMC3120268/ /pubmed/21716748 http://dx.doi.org/10.4103/0975-3583.78583 Text en Copyright: © Journal of Cardiovascular Disease Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Sliem, Hamdy
Nasr, Gamela
Left ventricular structure and function in prediabetic adults: Relationship with insulin resistance
title Left ventricular structure and function in prediabetic adults: Relationship with insulin resistance
title_full Left ventricular structure and function in prediabetic adults: Relationship with insulin resistance
title_fullStr Left ventricular structure and function in prediabetic adults: Relationship with insulin resistance
title_full_unstemmed Left ventricular structure and function in prediabetic adults: Relationship with insulin resistance
title_short Left ventricular structure and function in prediabetic adults: Relationship with insulin resistance
title_sort left ventricular structure and function in prediabetic adults: relationship with insulin resistance
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120268/
https://www.ncbi.nlm.nih.gov/pubmed/21716748
http://dx.doi.org/10.4103/0975-3583.78583
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