11,20-Dihy­droxy-3-oxopregna-1,4-dien-21-oic acid monohydrate

The title compound, C(21)H(28)O(5)·H(2)O, is the hydrate of a steroid derivative and was obtained by degradation of solid prednisolone sodium phosphate. The six C atoms in ring A are nearly co-planar with a mean deviation of 0.015 Å. Rings B and C are both in chair conformations, while ring D has an...

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Detalles Bibliográficos
Autores principales: Guo, Zhanqiang, Tang, Shengan, Duan, Hongquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2011
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120479/
https://www.ncbi.nlm.nih.gov/pubmed/21754697
http://dx.doi.org/10.1107/S1600536811015224
Descripción
Sumario:The title compound, C(21)H(28)O(5)·H(2)O, is the hydrate of a steroid derivative and was obtained by degradation of solid prednisolone sodium phosphate. The six C atoms in ring A are nearly co-planar with a mean deviation of 0.015 Å. Rings B and C are both in chair conformations, while ring D has an envelope form. In the crystal, inter­molecular O—H⋯O hydrogen-bonding inter­actions occur between the hy­droxy groups, carbonyl O atoms and solvent water mol­ecules, resulting in an overall three-dimensional structure.

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