Monosodium iodoacetate-induced joint pain is associated with increased phosphorylation of mitogen activated protein kinases in the rat spinal cord

BACKGROUND: Intra-articular injection of monosodium iodoacetate (MIA) in the knee joint of rats disrupts chondrocyte metabolism resulting in cartilage degeneration and subsequent nociceptive behavior that has been described as a model of osteoarthritis (OA) pain. Central sensitization through activa...

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Detalles Bibliográficos
Autores principales: Lee, Younglim, Pai, Madhavi, Brederson, Jill-Desiree, Wilcox, Denise, Hsieh, Gin, Jarvis, Michael F, Bitner, Robert S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120677/
https://www.ncbi.nlm.nih.gov/pubmed/21599960
http://dx.doi.org/10.1186/1744-8069-7-39

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