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Body Mass Index and Diabetes in Asia: A Cross-Sectional Pooled Analysis of 900,000 Individuals in the Asia Cohort Consortium
BACKGROUND: The occurrence of diabetes has greatly increased in low- and middle-income countries, particularly in Asia, as has the prevalence of overweight and obesity; in European-derived populations, overweight and obesity are established causes of diabetes. The shape of the association of overwei...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120751/ https://www.ncbi.nlm.nih.gov/pubmed/21731609 http://dx.doi.org/10.1371/journal.pone.0019930 |
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author | Boffetta, Paolo McLerran, Dale Chen, Yu Inoue, Manami Sinha, Rashmi He, Jiang Gupta, Prakash Chandra Tsugane, Shoichiro Irie, Fujiko Tamakoshi, Akiko Gao, Yu-Tang Shu, Xiao-Ou Wang, Renwei Tsuji, Ichiro Kuriyama, Shinichi Matsuo, Keitaro Satoh, Hiroshi Chen, Chien-Jen Yuan, Jian-Min Yoo, Keun-Young Ahsan, Habibul Pan, Wen-Harn Gu, Dongfeng Pednekar, Mangesh Suryakant Sasazuki, Shizuka Sairenchi, Toshimi Yang, Gong Xiang, Yong-Bing Nagai, Masato Tanaka, Hideo Nishino, Yoshikazu You, San-Lin Koh, Woon-Puay Park, Sue K. Shen, Chen-Yang Thornquist, Mark Kang, Daehee Rolland, Betsy Feng, Ziding Zheng, Wei Potter, John D. |
author_facet | Boffetta, Paolo McLerran, Dale Chen, Yu Inoue, Manami Sinha, Rashmi He, Jiang Gupta, Prakash Chandra Tsugane, Shoichiro Irie, Fujiko Tamakoshi, Akiko Gao, Yu-Tang Shu, Xiao-Ou Wang, Renwei Tsuji, Ichiro Kuriyama, Shinichi Matsuo, Keitaro Satoh, Hiroshi Chen, Chien-Jen Yuan, Jian-Min Yoo, Keun-Young Ahsan, Habibul Pan, Wen-Harn Gu, Dongfeng Pednekar, Mangesh Suryakant Sasazuki, Shizuka Sairenchi, Toshimi Yang, Gong Xiang, Yong-Bing Nagai, Masato Tanaka, Hideo Nishino, Yoshikazu You, San-Lin Koh, Woon-Puay Park, Sue K. Shen, Chen-Yang Thornquist, Mark Kang, Daehee Rolland, Betsy Feng, Ziding Zheng, Wei Potter, John D. |
author_sort | Boffetta, Paolo |
collection | PubMed |
description | BACKGROUND: The occurrence of diabetes has greatly increased in low- and middle-income countries, particularly in Asia, as has the prevalence of overweight and obesity; in European-derived populations, overweight and obesity are established causes of diabetes. The shape of the association of overweight and obesity with diabetes risk and its overall impact have not been adequately studied in Asia. METHODS AND FINDINGS: A pooled cross-sectional analysis was conducted to evaluate the association between baseline body mass index (BMI, measured as weight in kg divided by the square of height in m) and self-reported diabetes status in over 900,000 individuals recruited in 18 cohorts from Bangladesh, China, India, Japan, Korea, Singapore and Taiwan. Logistic regression models were fitted to calculate cohort-specific odds ratios (OR) of diabetes for categories of increasing BMI, after adjustment for potential confounding factors. OR were pooled across cohorts using a random-effects meta-analysis. The sex- and age-adjusted prevalence of diabetes was 4.3% in the overall population, ranging from 0.5% to 8.2% across participating cohorts. Using the category 22.5–24.9 Kg/m(2) as reference, the OR for diabetes spanned from 0.58 (95% confidence interval [CI] 0.31, 0.76) for BMI lower than 15.0 kg/m(2) to 2.23 (95% CI 1.86, 2.67) for BMI higher than 34.9 kg/m(2). The positive association between BMI and diabetes prevalence was present in all cohorts and in all subgroups of the study population, although the association was stronger in individuals below age 50 at baseline (p-value of interaction<0.001), in cohorts from India and Bangladesh (p<0.001), in individuals with low education (p-value 0.02), and in smokers (p-value 0.03); no differences were observed by gender, urban residence, or alcohol drinking. CONCLUSIONS: This study estimated the shape and the strength of the association between BMI and prevalence of diabetes in Asian populations and identified patterns of the association by age, country, and other risk factors for diabetes. |
format | Online Article Text |
id | pubmed-3120751 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-31207512011-06-30 Body Mass Index and Diabetes in Asia: A Cross-Sectional Pooled Analysis of 900,000 Individuals in the Asia Cohort Consortium Boffetta, Paolo McLerran, Dale Chen, Yu Inoue, Manami Sinha, Rashmi He, Jiang Gupta, Prakash Chandra Tsugane, Shoichiro Irie, Fujiko Tamakoshi, Akiko Gao, Yu-Tang Shu, Xiao-Ou Wang, Renwei Tsuji, Ichiro Kuriyama, Shinichi Matsuo, Keitaro Satoh, Hiroshi Chen, Chien-Jen Yuan, Jian-Min Yoo, Keun-Young Ahsan, Habibul Pan, Wen-Harn Gu, Dongfeng Pednekar, Mangesh Suryakant Sasazuki, Shizuka Sairenchi, Toshimi Yang, Gong Xiang, Yong-Bing Nagai, Masato Tanaka, Hideo Nishino, Yoshikazu You, San-Lin Koh, Woon-Puay Park, Sue K. Shen, Chen-Yang Thornquist, Mark Kang, Daehee Rolland, Betsy Feng, Ziding Zheng, Wei Potter, John D. PLoS One Research Article BACKGROUND: The occurrence of diabetes has greatly increased in low- and middle-income countries, particularly in Asia, as has the prevalence of overweight and obesity; in European-derived populations, overweight and obesity are established causes of diabetes. The shape of the association of overweight and obesity with diabetes risk and its overall impact have not been adequately studied in Asia. METHODS AND FINDINGS: A pooled cross-sectional analysis was conducted to evaluate the association between baseline body mass index (BMI, measured as weight in kg divided by the square of height in m) and self-reported diabetes status in over 900,000 individuals recruited in 18 cohorts from Bangladesh, China, India, Japan, Korea, Singapore and Taiwan. Logistic regression models were fitted to calculate cohort-specific odds ratios (OR) of diabetes for categories of increasing BMI, after adjustment for potential confounding factors. OR were pooled across cohorts using a random-effects meta-analysis. The sex- and age-adjusted prevalence of diabetes was 4.3% in the overall population, ranging from 0.5% to 8.2% across participating cohorts. Using the category 22.5–24.9 Kg/m(2) as reference, the OR for diabetes spanned from 0.58 (95% confidence interval [CI] 0.31, 0.76) for BMI lower than 15.0 kg/m(2) to 2.23 (95% CI 1.86, 2.67) for BMI higher than 34.9 kg/m(2). The positive association between BMI and diabetes prevalence was present in all cohorts and in all subgroups of the study population, although the association was stronger in individuals below age 50 at baseline (p-value of interaction<0.001), in cohorts from India and Bangladesh (p<0.001), in individuals with low education (p-value 0.02), and in smokers (p-value 0.03); no differences were observed by gender, urban residence, or alcohol drinking. CONCLUSIONS: This study estimated the shape and the strength of the association between BMI and prevalence of diabetes in Asian populations and identified patterns of the association by age, country, and other risk factors for diabetes. Public Library of Science 2011-06-22 /pmc/articles/PMC3120751/ /pubmed/21731609 http://dx.doi.org/10.1371/journal.pone.0019930 Text en Boffetta et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Boffetta, Paolo McLerran, Dale Chen, Yu Inoue, Manami Sinha, Rashmi He, Jiang Gupta, Prakash Chandra Tsugane, Shoichiro Irie, Fujiko Tamakoshi, Akiko Gao, Yu-Tang Shu, Xiao-Ou Wang, Renwei Tsuji, Ichiro Kuriyama, Shinichi Matsuo, Keitaro Satoh, Hiroshi Chen, Chien-Jen Yuan, Jian-Min Yoo, Keun-Young Ahsan, Habibul Pan, Wen-Harn Gu, Dongfeng Pednekar, Mangesh Suryakant Sasazuki, Shizuka Sairenchi, Toshimi Yang, Gong Xiang, Yong-Bing Nagai, Masato Tanaka, Hideo Nishino, Yoshikazu You, San-Lin Koh, Woon-Puay Park, Sue K. Shen, Chen-Yang Thornquist, Mark Kang, Daehee Rolland, Betsy Feng, Ziding Zheng, Wei Potter, John D. Body Mass Index and Diabetes in Asia: A Cross-Sectional Pooled Analysis of 900,000 Individuals in the Asia Cohort Consortium |
title | Body Mass Index and Diabetes in Asia: A Cross-Sectional Pooled Analysis of 900,000 Individuals in the Asia Cohort Consortium |
title_full | Body Mass Index and Diabetes in Asia: A Cross-Sectional Pooled Analysis of 900,000 Individuals in the Asia Cohort Consortium |
title_fullStr | Body Mass Index and Diabetes in Asia: A Cross-Sectional Pooled Analysis of 900,000 Individuals in the Asia Cohort Consortium |
title_full_unstemmed | Body Mass Index and Diabetes in Asia: A Cross-Sectional Pooled Analysis of 900,000 Individuals in the Asia Cohort Consortium |
title_short | Body Mass Index and Diabetes in Asia: A Cross-Sectional Pooled Analysis of 900,000 Individuals in the Asia Cohort Consortium |
title_sort | body mass index and diabetes in asia: a cross-sectional pooled analysis of 900,000 individuals in the asia cohort consortium |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120751/ https://www.ncbi.nlm.nih.gov/pubmed/21731609 http://dx.doi.org/10.1371/journal.pone.0019930 |
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