New Topoisomerase I mutations are associated with resistance to camptothecin

BACKGROUND: Topoisomerase I (TOP1) is a nuclear enzyme that catalyzes the relaxation of supercoiled DNA during DNA replication and transcription. TOP1 is the molecular target of camptothecin and related drugs such as irinotecan and SN38 (irinotecan's active metabolite). Irinotecan is widely use...

Descripción completa

Detalles Bibliográficos
Autores principales: Gongora, Céline, Vezzio-Vie, Nadia, Tuduri, Sandie, Denis, Vincent, Causse, Annick, Auzanneau, Céline, Collod-Beroud, Gwenaëlle, Coquelle, Arnaud, Pasero, Philippe, Pourquier, Philippe, Martineau, Pierre, Del Rio, Maguy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120799/
https://www.ncbi.nlm.nih.gov/pubmed/21619602
http://dx.doi.org/10.1186/1476-4598-10-64

Ejemplares similares

Ejemplares similares