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In vitro anti-angiogenic properties of LGD1069, a selective retinoid X-receptor agonist through down-regulating Runx2 expression on Human endothelial cells

BACKGROUND: LGD1069 (Targretin(®)) is a selective retinoid X receptor (RXR) ligand, which is used in patients for cutaneous T-cell lymphoma. Our published study reported that LGD1069 inhibited tumor-induced angiogenesis in non-small cell lung cancer. In present study, we found that LGD1069 suppresse...

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Detalles Bibliográficos
Autores principales:	Fu, Jianjiang, Wang, Wei, Liu, Yu-Hui, Lu, Hong, Luo, Yongming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120806/ https://www.ncbi.nlm.nih.gov/pubmed/21649908 http://dx.doi.org/10.1186/1471-2407-11-227

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