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An Observational Cohort Study of the Kynurenine to Tryptophan Ratio in Sepsis: Association with Impaired Immune and Microvascular Function

Both endothelial and immune dysfunction contribute to the high mortality rate in human sepsis, but the underlying mechanisms are unclear. In response to infection, interferon-γ activates indoleamine 2,3-dioxygenase (IDO) which metabolizes the essential amino acid tryptophan to the toxic metabolite k...

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Detalles Bibliográficos
Autores principales:	Darcy, Christabelle J., Davis, Joshua S., Woodberry, Tonia, McNeil, Yvette R., Stephens, Dianne P., Yeo, Tsin W., Anstey, Nicholas M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120841/ https://www.ncbi.nlm.nih.gov/pubmed/21731667 http://dx.doi.org/10.1371/journal.pone.0021185

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