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An Observational Cohort Study of the Kynurenine to Tryptophan Ratio in Sepsis: Association with Impaired Immune and Microvascular Function
Both endothelial and immune dysfunction contribute to the high mortality rate in human sepsis, but the underlying mechanisms are unclear. In response to infection, interferon-γ activates indoleamine 2,3-dioxygenase (IDO) which metabolizes the essential amino acid tryptophan to the toxic metabolite k...
Autores principales: | Darcy, Christabelle J., Davis, Joshua S., Woodberry, Tonia, McNeil, Yvette R., Stephens, Dianne P., Yeo, Tsin W., Anstey, Nicholas M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120841/ https://www.ncbi.nlm.nih.gov/pubmed/21731667 http://dx.doi.org/10.1371/journal.pone.0021185 |
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