Daidzein Prevents the Increase in CD4(+)CD28null T Cells and B Lymphopoesis in Ovariectomized Mice: A Key Mechanism for Anti-Osteoclastogenic Effect

Estrogen deficiency leads to an upregulation of TNF-α producing T cells and B-lymphopoesis which augments osteoclastogenesis. Estrogen deficiency also increases the population of premature senescent CD4(+)CD28null T cells which secrete a higher amount of TNF-α thus leading to enhanced osteoclastogen...

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Detalles Bibliográficos
Autores principales: Tyagi, Abdul Malik, Srivastava, Kamini, Sharan, Kunal, Yadav, Dinesh, Maurya, Rakesh, Singh, Divya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120851/
https://www.ncbi.nlm.nih.gov/pubmed/21731677
http://dx.doi.org/10.1371/journal.pone.0021216

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