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Recognition of 5-Hydroxymethylcytosine by the Uhrf1 SRA Domain

Recent discovery of 5-hydroxymethylcytosine (5hmC) in genomic DNA raises the question how this sixth base is recognized by cellular proteins. In contrast to the methyl-CpG binding domain (MBD) of MeCP2, we found that the SRA domain of Uhrf1, an essential factor in DNA maintenance methylation, binds...

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Detalles Bibliográficos
Autores principales:	Frauer, Carina, Hoffmann, Thomas, Bultmann, Sebastian, Casa, Valentina, Cardoso, M. Cristina, Antes, Iris, Leonhardt, Heinrich
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120858/ https://www.ncbi.nlm.nih.gov/pubmed/21731699 http://dx.doi.org/10.1371/journal.pone.0021306

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