Mitochondrial Oxidative Phosphorylation Compensation May Preserve Vision in Patients with OPA1-Linked Autosomal Dominant Optic Atrophy

Autosomal Dominant Optic Atrophy (ADOA) is the most common inherited optic atrophy where vision impairment results from specific loss of retinal ganglion cells of the optic nerve. Around 60% of ADOA cases are linked to mutations in the OPA1 gene. OPA1 is a fission-fusion protein involved in mitochon...

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Detalles Bibliográficos
Autores principales: Van Bergen, Nicole J., Crowston, Jonathan G., Kearns, Lisa S., Staffieri, Sandra E., Hewitt, Alex W., Cohn, Amy C., Mackey, David A., Trounce, Ian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120866/
https://www.ncbi.nlm.nih.gov/pubmed/21731710
http://dx.doi.org/10.1371/journal.pone.0021347

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120866/
https://www.ncbi.nlm.nih.gov/pubmed/21731710
http://dx.doi.org/10.1371/journal.pone.0021347

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