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Multiple Insulin Degrading Enzyme Variants Alter In Vitro Reporter Gene Expression

The insulin degrading enzyme (IDE) variant, v311 (rs6583817), is associated with increased post-mortem cerebellar IDE mRNA, decreased plasma β-amyloid (Aβ), decreased risk for Alzheimer's disease (AD) and increased reporter gene expression, suggesting that it is a functional variant driving inc...

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Detalles Bibliográficos
Autores principales:	Belbin, Olivia, Crump, Michael, Bisceglio, Gina D., Carrasquillo, Minerva M., Morgan, Kevin, Younkin, Steven G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120874/ https://www.ncbi.nlm.nih.gov/pubmed/21731745 http://dx.doi.org/10.1371/journal.pone.0021429

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