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Prevalence of helicobacter pylori among Nigerian patients with dyspepsia in Ibadan

INTRODUCTION: Determination of the true prevalence of Helicobacter pylori ( H. pylori) is difficult in a hyper-endemic area like Nigeria with use of serological tests because of their low discriminatory power between previous and current infections. The use of biopsy based methods will go a long way...

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Autores principales: Abiodun Christopher, Jemilohun, Jesse Abiodun, Otegbayo, Samuel Olawale, Ola, Olayiwola Abideen, Oluwasola, Adegboyega, Akere
Formato: Online Artículo Texto
Lenguaje:English
Publicado: African Field Epidemiology Network 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120989/
https://www.ncbi.nlm.nih.gov/pubmed/21734925
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author Abiodun Christopher, Jemilohun
Jesse Abiodun, Otegbayo
Samuel Olawale, Ola
Olayiwola Abideen, Oluwasola
Adegboyega, Akere
author_facet Abiodun Christopher, Jemilohun
Jesse Abiodun, Otegbayo
Samuel Olawale, Ola
Olayiwola Abideen, Oluwasola
Adegboyega, Akere
author_sort Abiodun Christopher, Jemilohun
collection PubMed
description INTRODUCTION: Determination of the true prevalence of Helicobacter pylori ( H. pylori) is difficult in a hyper-endemic area like Nigeria with use of serological tests because of their low discriminatory power between previous and current infections. The use of biopsy based methods will go a long way to mitigate this problem. We investigated the prevalence of H. pylori in dyspeptic patients and its relationship with gastroduodenal pathologies using gastric biopsy histology and rapid urease test. METHODS: Eighty-six consecutive adult patients with dyspepsia underwent upper gastrointestinal endoscopy using forward-viewing endoscopes. Antral biopsy specimens were collected for histology and rapid urease test. Diagnosis of H. pylori infection was made if both or either of the tests was positive. RESULTS: Of the 86 subjects, there were 39 (45.3%) males and 47(54.7%) females. The age range was 23 to 85 years with a mean of 49.19±13.75 years. Diagnosis of H. pylori was made in 55(64%) patients. Gastritis was the commonest endoscopic finding (60.5%), serious gastroduodenal pathology (gastric ulcer, duodenal ulcer and gastric cancer) were documented in only 12 (14%) patients. Thirty three (63.5%) of the 55 patients with gastritis had H. pylori infection while 7(58.3%) of the 12 patients with serious gastroduodenal lesions had the infection. Thirteen (72.2%) of the 18 patients that had normal endoscopic findings were H. pylori positive. CONCLUSION: The prevalence of H. pylori among dyspeptics using biopsy based methods is high in the South-Western part of Nigeria. It is therefore important to test and treat H. pylori among Nigerians with dyspepsia.
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spelling pubmed-31209892011-07-06 Prevalence of helicobacter pylori among Nigerian patients with dyspepsia in Ibadan Abiodun Christopher, Jemilohun Jesse Abiodun, Otegbayo Samuel Olawale, Ola Olayiwola Abideen, Oluwasola Adegboyega, Akere Pan Afr Med J Life Sciences INTRODUCTION: Determination of the true prevalence of Helicobacter pylori ( H. pylori) is difficult in a hyper-endemic area like Nigeria with use of serological tests because of their low discriminatory power between previous and current infections. The use of biopsy based methods will go a long way to mitigate this problem. We investigated the prevalence of H. pylori in dyspeptic patients and its relationship with gastroduodenal pathologies using gastric biopsy histology and rapid urease test. METHODS: Eighty-six consecutive adult patients with dyspepsia underwent upper gastrointestinal endoscopy using forward-viewing endoscopes. Antral biopsy specimens were collected for histology and rapid urease test. Diagnosis of H. pylori infection was made if both or either of the tests was positive. RESULTS: Of the 86 subjects, there were 39 (45.3%) males and 47(54.7%) females. The age range was 23 to 85 years with a mean of 49.19±13.75 years. Diagnosis of H. pylori was made in 55(64%) patients. Gastritis was the commonest endoscopic finding (60.5%), serious gastroduodenal pathology (gastric ulcer, duodenal ulcer and gastric cancer) were documented in only 12 (14%) patients. Thirty three (63.5%) of the 55 patients with gastritis had H. pylori infection while 7(58.3%) of the 12 patients with serious gastroduodenal lesions had the infection. Thirteen (72.2%) of the 18 patients that had normal endoscopic findings were H. pylori positive. CONCLUSION: The prevalence of H. pylori among dyspeptics using biopsy based methods is high in the South-Western part of Nigeria. It is therefore important to test and treat H. pylori among Nigerians with dyspepsia. African Field Epidemiology Network 2010-09-19 /pmc/articles/PMC3120989/ /pubmed/21734925 Text en Copyright © Abiodun Christopher Jemilohun et al. http://creativecommons.org/licenses/by/2.0/ The Pan African Medical Journal - ISSN 1937-8688. This is an Open Access article distributed under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Life Sciences
Abiodun Christopher, Jemilohun
Jesse Abiodun, Otegbayo
Samuel Olawale, Ola
Olayiwola Abideen, Oluwasola
Adegboyega, Akere
Prevalence of helicobacter pylori among Nigerian patients with dyspepsia in Ibadan
title Prevalence of helicobacter pylori among Nigerian patients with dyspepsia in Ibadan
title_full Prevalence of helicobacter pylori among Nigerian patients with dyspepsia in Ibadan
title_fullStr Prevalence of helicobacter pylori among Nigerian patients with dyspepsia in Ibadan
title_full_unstemmed Prevalence of helicobacter pylori among Nigerian patients with dyspepsia in Ibadan
title_short Prevalence of helicobacter pylori among Nigerian patients with dyspepsia in Ibadan
title_sort prevalence of helicobacter pylori among nigerian patients with dyspepsia in ibadan
topic Life Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120989/
https://www.ncbi.nlm.nih.gov/pubmed/21734925
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