Mapping the IκB Kinase β (IKKβ)-binding Interface of the B14 Protein, a Vaccinia Virus Inhibitor of IKKβ-mediated Activation of Nuclear Factor κB

The IκB kinase (IKK) complex regulates activation of NF-κB, a critical transcription factor in mediating inflammatory and immune responses. Not surprisingly, therefore, many viruses seek to inhibit NF-κB activation. The vaccinia virus B14 protein contributes to virus virulence by binding to the IKKβ...

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Detalles Bibliográficos
Autores principales: Benfield, Camilla T. O., Mansur, Daniel S., McCoy, Laura E., Ferguson, Brian J., Bahar, Mohammad W., Oldring, Asa P., Grimes, Jonathan M., Stuart, David I., Graham, Stephen C., Smith, Geoffrey L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Protein Structure and Folding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121528/
https://www.ncbi.nlm.nih.gov/pubmed/21474453
http://dx.doi.org/10.1074/jbc.M111.231381

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