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An association between Helicobacter pylori infection and cognitive function in children at early school age: a community-based study

BACKGROUND: H. pylori infection has been linked to iron deficiency anemia, a risk factor of diminished cognitive development. The hypothesis on an association between H. pylori infection and cognitive function was examined in healthy children, independently of socioeconomic and nutritional factors....

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Detalles Bibliográficos
Autores principales: Muhsen, Khitam, Ornoy, Asher, Akawi, Ashraf, Alpert, Gershon, Cohen, Dani
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121602/
https://www.ncbi.nlm.nih.gov/pubmed/21612616
http://dx.doi.org/10.1186/1471-2431-11-43
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author Muhsen, Khitam
Ornoy, Asher
Akawi, Ashraf
Alpert, Gershon
Cohen, Dani
author_facet Muhsen, Khitam
Ornoy, Asher
Akawi, Ashraf
Alpert, Gershon
Cohen, Dani
author_sort Muhsen, Khitam
collection PubMed
description BACKGROUND: H. pylori infection has been linked to iron deficiency anemia, a risk factor of diminished cognitive development. The hypothesis on an association between H. pylori infection and cognitive function was examined in healthy children, independently of socioeconomic and nutritional factors. METHODS: A community-based study was conducted among 200 children aged 6-9 years, from different socioeconomic background. H. pylori infection was examined by an ELISA kit for detection of H. pylori antigen in stool samples. Cognitive function of the children was blindly assessed using Stanford-Benit test 5(th )edition, yielding IQ scores. Data on socioeconomic factors and nutritional covariates were collected through maternal interviews and from medical records. Multivariate linear regression analysis was performed to obtain adjusted beta coefficients. RESULTS: H. pylori infection was associated with lower IQ scores only in children from a relatively higher socioeconomic community; adjusted beta coefficient -6.1 (95% CI -11.4, -0.8) (P = 0.02) for full-scale IQ score, -6.0 (95% CI -11.1, -0.2) (P = 0.04) for non-verbal IQ score and -5.7 (95% CI -10.8, -0.6) (P = 0.02) for verbal IQ score, after controlling for potential confounders. CONCLUSIONS: H. pylori infection might be negatively involved in cognitive development at early school age. Further studies in other populations with larger samples are needed to confirm this novel finding.
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spelling pubmed-31216022011-06-24 An association between Helicobacter pylori infection and cognitive function in children at early school age: a community-based study Muhsen, Khitam Ornoy, Asher Akawi, Ashraf Alpert, Gershon Cohen, Dani BMC Pediatr Research Article BACKGROUND: H. pylori infection has been linked to iron deficiency anemia, a risk factor of diminished cognitive development. The hypothesis on an association between H. pylori infection and cognitive function was examined in healthy children, independently of socioeconomic and nutritional factors. METHODS: A community-based study was conducted among 200 children aged 6-9 years, from different socioeconomic background. H. pylori infection was examined by an ELISA kit for detection of H. pylori antigen in stool samples. Cognitive function of the children was blindly assessed using Stanford-Benit test 5(th )edition, yielding IQ scores. Data on socioeconomic factors and nutritional covariates were collected through maternal interviews and from medical records. Multivariate linear regression analysis was performed to obtain adjusted beta coefficients. RESULTS: H. pylori infection was associated with lower IQ scores only in children from a relatively higher socioeconomic community; adjusted beta coefficient -6.1 (95% CI -11.4, -0.8) (P = 0.02) for full-scale IQ score, -6.0 (95% CI -11.1, -0.2) (P = 0.04) for non-verbal IQ score and -5.7 (95% CI -10.8, -0.6) (P = 0.02) for verbal IQ score, after controlling for potential confounders. CONCLUSIONS: H. pylori infection might be negatively involved in cognitive development at early school age. Further studies in other populations with larger samples are needed to confirm this novel finding. BioMed Central 2011-05-25 /pmc/articles/PMC3121602/ /pubmed/21612616 http://dx.doi.org/10.1186/1471-2431-11-43 Text en Copyright ©2011 Muhsen et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Muhsen, Khitam
Ornoy, Asher
Akawi, Ashraf
Alpert, Gershon
Cohen, Dani
An association between Helicobacter pylori infection and cognitive function in children at early school age: a community-based study
title An association between Helicobacter pylori infection and cognitive function in children at early school age: a community-based study
title_full An association between Helicobacter pylori infection and cognitive function in children at early school age: a community-based study
title_fullStr An association between Helicobacter pylori infection and cognitive function in children at early school age: a community-based study
title_full_unstemmed An association between Helicobacter pylori infection and cognitive function in children at early school age: a community-based study
title_short An association between Helicobacter pylori infection and cognitive function in children at early school age: a community-based study
title_sort association between helicobacter pylori infection and cognitive function in children at early school age: a community-based study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121602/
https://www.ncbi.nlm.nih.gov/pubmed/21612616
http://dx.doi.org/10.1186/1471-2431-11-43
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