Cargando…

Dexamethasone inhibits the Nox-dependent ROS production via suppression of MKP-1-dependent MAPK pathways in activated microglia

BACKGROUND: Nox-2 (also known as gp91phox), a subunit component of NADPH oxidases, generates reactive oxygen species (ROS). Nox-dependent ROS generation and nitric oxide (NO) release by microglia have been implicated in a variety of diseases in the central nervous system. Dexamethasone (Dex) has bee...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huo, Yingqian, Rangarajan, Parakalan, Ling, Eng-Ang, Dheen, S Thameem
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121618/ https://www.ncbi.nlm.nih.gov/pubmed/21615929 http://dx.doi.org/10.1186/1471-2202-12-49

Ejemplares similares

Transcriptome analysis of amoeboid and ramified microglia isolated from the corpus callosum of rat brain
por: Parakalan, Rangarajan, et al.
Publicado: (2012)

Anti-inflammatory effects of Edaravone and Scutellarin in activated microglia in experimentally induced ischemia injury in rats and in BV-2 microglia
por: Yuan, Yun, et al.
Publicado: (2014)

Runx1t1 (Runt-Related Transcription Factor 1; Translocated to, 1) Epigenetically Regulates the Proliferation and Nitric Oxide Production of Microglia
por: Baby, Nimmi, et al.
Publicado: (2014)

Scutellarin regulates the Notch pathway and affects the migration and morphological transformation of activated microglia in experimentally induced cerebral ischemia in rats and in activated BV-2 microglia
por: Yuan, Yun, et al.
Publicado: (2015)

Production of proinflammatory mediators in activated microglia is synergistically regulated by Notch-1, glycogen synthase kinase (GSK-3β) and NF-κB/p65 signalling
por: Cao, Qiong, et al.
Publicado: (2017)

Notch-1 Signaling Regulates Microglia Activation via NF-κB Pathway after Hypoxic Exposure In Vivo and In Vitro
por: Yao, Linli, et al.
Publicado: (2013)

Scutellarin regulates microglia-mediated TNC1 astrocytic reaction and astrogliosis in cerebral ischemia in the adult rats
por: Fang, Ming, et al.
Publicado: (2015)

A paradigm shift: emerging roles of microglia, a non-neuronal cell, in learning and memory
por: Gupta, Neelima, et al.
Publicado: (2021)

Toll-like receptor 4 mediates microglial activation and production of inflammatory mediators in neonatal rat brain following hypoxia: role of TLR4 in hypoxic microglia
por: Yao, Linli, et al.
Publicado: (2013)

NOX Dependent ROS Generation and Cell Metabolism
por: Pecchillo Cimmino, Tiziana, et al.
Publicado: (2023)

Microglial SMAD4 regulated by microRNA-146a promotes migration of microglia which support tumor progression in a glioma environment
por: Karthikeyan, Aparna, et al.
Publicado: (2018)

Nox4-dependent ROS modulation by amino endoperoxides to induce apoptosis in cancer cells
por: Zhu, P, et al.
Publicado: (2013)

Impact of Nox5 Polymorphisms on Basal and Stimulus-Dependent ROS Generation
por: Wang, Yusi, et al.
Publicado: (2014)

Dexamethasone Attenuates the Expression of MMP-13 in Chondrocytes through MKP-1
por: Lehtola, Tiina, et al.
Publicado: (2022)

Achyranthes bidentata polypeptide alleviates neurotoxicity of lipopolysaccharide-activated microglia via PI3K/Akt dependent NOX2/ROS pathway
por: Wang, Yitong, et al.
Publicado: (2021)

Melatonin Suppresses Toll Like Receptor 4-Dependent Caspase-3 Signaling Activation Coupled with Reduced Production of Proinflammatory Mediators in Hypoxic Microglia
por: Yao, Linli, et al.
Publicado: (2016)

An MKP-MAPK protein phosphorylation cascade controls vascular immunity in plants
por: Lin, Hui, et al.
Publicado: (2022)

Expression of sphingosine kinase 1 in amoeboid microglial cells in the corpus callosum of postnatal rats
por: Lin, Haiyan, et al.
Publicado: (2011)

miR-142-3p Regulates BDNF Expression in Activated Rodent Microglia Through Its Target CAMK2A
por: Gupta, Neelima, et al.
Publicado: (2020)

Forsythiaside A Regulates Activation of Hepatic Stellate Cells by Inhibiting NOX4-Dependent ROS
por: Zhou, Mengting, et al.
Publicado: (2022)

Correction: Alamandine attenuates hepatic fibrosis by regulating autophagy induced by NOX4-dependent ROS
Publicado: (2021)

MKP-1 overexpression is associated with chemoresistance in bladder cancer via the MAPK pathway
por: Lei, Siyu, et al.
Publicado: (2020)

Expression of Concern: Alamandine attenuates hepatic fibrosis by regulating autophagy induced by NOX4-dependent ROS
Publicado: (2020)

Therapeutic targeting of pancreatic cancer stem cells by dexamethasone modulation of the MKP-1–JNK axis
por: Suzuki, Shuhei, et al.
Publicado: (2021)

SOCS3 Attenuates Dexamethasone-Induced M2 Polarization by Down-Regulation of GILZ via ROS- and p38 MAPK-Dependent Pathways
por: Jeong, Hana, et al.
Publicado: (2022)

Induction of MAPK- and ROS-dependent autophagy and apoptosis in gastric carcinoma by combination of romidepsin and bortezomib
por: Hui, Kwai Fung, et al.
Publicado: (2015)

Functional analysis of MKP-1 and MKP-2 in breast cancer tamoxifen sensitivity
por: Haagenson, Kelly K., et al.
Publicado: (2014)

Inhibition of p38 MAPK Signaling Augments Skin Tumorigenesis via NOX2 Driven ROS Generation
por: Liu, Liang, et al.
Publicado: (2014)

Silver Nanoparticle-Induced Apoptosis in ARPE-19 Cells Is Inhibited by Toxoplasma gondii Pre-Infection Through Suppression of NOX4-Dependent ROS Generation
por: Quan, Juan-Hua, et al.
Publicado: (2020)

NOX4-dependent ROS production by stromal mammary cells modulates epithelial MCF-7 cell migration
por: Tobar, N, et al.
Publicado: (2010)

TGF-β3 Induces Autophagic Activity by Increasing ROS Generation in a NOX4-Dependent Pathway
por: Zhang, Yun, et al.
Publicado: (2019)

Microglia involvement in sex-dependent behaviors and schizophrenia occurrence in offspring with maternal dexamethasone exposure
por: Rim, Chan, et al.
Publicado: (2022)

MKP-3 suppresses LPS-induced inflammatory responses in HUVECs via inhibition of p38 MAPK/NF-κB pathway
por: Unenkhuu, Banzragchgarav, et al.
Publicado: (2021)

MsrA Suppresses Inflammatory Activation of Microglia and Oxidative Stress to Prevent Demyelination via Inhibition of the NOX2-MAPKs/NF-κB Signaling Pathway
por: Fan, Hua, et al.
Publicado: (2020)

NOX- and ROS-Driven Hypertension in Elastin Insufficiency
por: Gavazzi, Gaëtan, et al.
Publicado: (2021)

NOX-like ROS production by glutathione reductase
por: Diaz, Julia M., et al.
Publicado: (2022)

Dual control of MAPK activities by AP2C1 and MKP1 MAPK phosphatases regulates defence responses in Arabidopsis
por: Ayatollahi, Zahra, et al.
Publicado: (2022)

Erratum: Functional analysis of MKP-1 and MKP-2 in breast cancer tamoxifen sensitivity
por: Haagenson, Kelly K., et al.
Publicado: (2018)

MKP-1 suppresses PARP-1 degradation to mediate cisplatin resistance
por: Wang, Juan, et al.
Publicado: (2017)

MKP-4 suppresses hepatocarcinogenesis by targeting ERK1/2 pathway
por: Shen, Zhongyi, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_elfkug5e16d82k75rgf12ha052