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Childhood meat eating and inflammatory markers: The Guangzhou Biobank Cohort Study

BACKGROUND: We hypothesized that socio-economic development could, via nutritionally driven levels of pubertal sex-steroids, promote a pro-inflammatory state among men but not women in developing countries. We tested this hypothesis, using recalled childhood meat eating as a proxy for childhood nutr...

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Detalles Bibliográficos
Autores principales: Schooling, CM, Jiang, CQ, Lam, TH, Zhang, WS, Cheng, KK, Leung, GM
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121633/
https://www.ncbi.nlm.nih.gov/pubmed/21595911
http://dx.doi.org/10.1186/1471-2458-11-345
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author Schooling, CM
Jiang, CQ
Lam, TH
Zhang, WS
Cheng, KK
Leung, GM
author_facet Schooling, CM
Jiang, CQ
Lam, TH
Zhang, WS
Cheng, KK
Leung, GM
author_sort Schooling, CM
collection PubMed
description BACKGROUND: We hypothesized that socio-economic development could, via nutritionally driven levels of pubertal sex-steroids, promote a pro-inflammatory state among men but not women in developing countries. We tested this hypothesis, using recalled childhood meat eating as a proxy for childhood nutrition, in southern China. METHODS: We used multivariable linear regression in the Guangzhou Biobank Cohort Study phase 3 (2006-8) to examine the adjusted associations of recalled childhood meat eating, <1/week (n = 5,023), about once per week (n = 3,592) and almost daily (n = 1,252), with white blood cell count and its differentials among older (≥50 years) men (n = 2,498) and women (n = 7,369). RESULTS: Adjusted for age, childhood socio-economic position, education and smoking, childhood meat eating had sex-specific associations with white blood cell count and lymphocyte count, but not granulocyte count. Men with childhood meat eating almost daily compared to <1/week had higher white blood cell count (0.33 10(9)/L, 95% confidence interval (CI) 0.10 to 0.56) and higher lymphocyte count (0.16 10(9)/L, 95% CI 0.07 to 0.25). Adjustment for obesity slightly attenuated these associations. CONCLUSION: If confirmed, this hypothesis implies that economic development and the associated improvements in nutrition at puberty may be less beneficial among men than women; consistent with the widening sex differentials in life expectancy with economic development.
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spelling pubmed-31216332011-06-24 Childhood meat eating and inflammatory markers: The Guangzhou Biobank Cohort Study Schooling, CM Jiang, CQ Lam, TH Zhang, WS Cheng, KK Leung, GM BMC Public Health Research Article BACKGROUND: We hypothesized that socio-economic development could, via nutritionally driven levels of pubertal sex-steroids, promote a pro-inflammatory state among men but not women in developing countries. We tested this hypothesis, using recalled childhood meat eating as a proxy for childhood nutrition, in southern China. METHODS: We used multivariable linear regression in the Guangzhou Biobank Cohort Study phase 3 (2006-8) to examine the adjusted associations of recalled childhood meat eating, <1/week (n = 5,023), about once per week (n = 3,592) and almost daily (n = 1,252), with white blood cell count and its differentials among older (≥50 years) men (n = 2,498) and women (n = 7,369). RESULTS: Adjusted for age, childhood socio-economic position, education and smoking, childhood meat eating had sex-specific associations with white blood cell count and lymphocyte count, but not granulocyte count. Men with childhood meat eating almost daily compared to <1/week had higher white blood cell count (0.33 10(9)/L, 95% confidence interval (CI) 0.10 to 0.56) and higher lymphocyte count (0.16 10(9)/L, 95% CI 0.07 to 0.25). Adjustment for obesity slightly attenuated these associations. CONCLUSION: If confirmed, this hypothesis implies that economic development and the associated improvements in nutrition at puberty may be less beneficial among men than women; consistent with the widening sex differentials in life expectancy with economic development. BioMed Central 2011-05-19 /pmc/articles/PMC3121633/ /pubmed/21595911 http://dx.doi.org/10.1186/1471-2458-11-345 Text en Copyright ©2011 Schooling et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Schooling, CM
Jiang, CQ
Lam, TH
Zhang, WS
Cheng, KK
Leung, GM
Childhood meat eating and inflammatory markers: The Guangzhou Biobank Cohort Study
title Childhood meat eating and inflammatory markers: The Guangzhou Biobank Cohort Study
title_full Childhood meat eating and inflammatory markers: The Guangzhou Biobank Cohort Study
title_fullStr Childhood meat eating and inflammatory markers: The Guangzhou Biobank Cohort Study
title_full_unstemmed Childhood meat eating and inflammatory markers: The Guangzhou Biobank Cohort Study
title_short Childhood meat eating and inflammatory markers: The Guangzhou Biobank Cohort Study
title_sort childhood meat eating and inflammatory markers: the guangzhou biobank cohort study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121633/
https://www.ncbi.nlm.nih.gov/pubmed/21595911
http://dx.doi.org/10.1186/1471-2458-11-345
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