Concurrent detection of autolysosome formation and lysosomal degradation by flow cytometry in a high-content screen for inducers of autophagy

BACKGROUND: Autophagy mediates lysosomal degradation of cytosolic components. Recent work has associated autophagic dysfunction with pathologies, including cancer and cardiovascular disease. To date, the identification of clinically-applicable drugs that modulate autophagy has been hampered by the l...

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Detalles Bibliográficos
Autores principales: Hundeshagen, Phillip, Hamacher-Brady, Anne, Eils, Roland, Brady, Nathan R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121655/
https://www.ncbi.nlm.nih.gov/pubmed/21635740
http://dx.doi.org/10.1186/1741-7007-9-38

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121655/
https://www.ncbi.nlm.nih.gov/pubmed/21635740
http://dx.doi.org/10.1186/1741-7007-9-38

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