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Graded Nodal/Activin Signaling Titrates Conversion of Quantitative Phospho-Smad2 Levels into Qualitative Embryonic Stem Cell Fate Decisions

Nodal and Activin are morphogens of the TGFbeta superfamily of signaling molecules that direct differential cell fate decisions in a dose- and distance-dependent manner. During early embryonic development the Nodal/Activin pathway is responsible for the specification of mesoderm, endoderm, node, and...

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Detalles Bibliográficos
Autores principales:	Lee, Kian Leong, Lim, Sandy Keat, Orlov, Yuriy Lvovich, Yit, Le Yau, Yang, Henry, Ang, Lay Teng, Poellinger, Lorenz, Lim, Bing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121749/ https://www.ncbi.nlm.nih.gov/pubmed/21731500 http://dx.doi.org/10.1371/journal.pgen.1002130

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