Elevated BCRP/ABCG2 Expression Confers Acquired Resistance to Gefitinib in Wild-Type EGFR-Expressing Cells

BACKGROUND: The sensitivity of non-small cell lung cancer (NSCLC) patients to EGFR tyrosine kinase inhibitors (TKIs) is strongly associated with activating EGFR mutations. Although not as sensitive as patients harboring these mutations, some patients with wild-type EGFR (wtEGFR) remain responsive to...

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Detalles Bibliográficos
Autores principales: Chen, Yun-Ju, Huang, Wei-Chien, Wei, Ya-Ling, Hsu, Sheng-Chieh, Yuan, Ping, Lin, Heather Y., Wistuba, Ignacio I., Lee, J. Jack, Yen, Chia-Jui, Su, Wu-Chou, Chang, Kwang-Yu, Chang, Wen-Chang, Chou, Tse-Chuan, Chou, Chao-Kai, Tsai, Chang-Hai, Hung, Mien-Chie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121773/
https://www.ncbi.nlm.nih.gov/pubmed/21731744
http://dx.doi.org/10.1371/journal.pone.0021428

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121773/
https://www.ncbi.nlm.nih.gov/pubmed/21731744
http://dx.doi.org/10.1371/journal.pone.0021428

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