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Mechanism of Heparin Acceleration of Tissue Inhibitor of Metalloproteases-1 (TIMP-1) Degradation by the Human Neutrophil Elastase

Heparin has been shown to regulate human neutrophil elastase (HNE) activity. We have assessed the regulatory effect of heparin on Tissue Inhibitor of Metalloproteases-1 [TIMP-1] hydrolysis by HNE employing the recombinant form of TIMP-1 and correlated FRET-peptides comprising the TIMP-1 cleavage sit...

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Detalles Bibliográficos
Autores principales:	Nunes, Gabriel L. C., Simões, Alyne, Dyszy, Fábio H., Shida, Claudio S., Juliano, Maria A., Juliano, Luiz, Gesteira, Tarsis F., Nader, Helena B., Murphy, Gillian, Chaffotte, Alain F., Goldberg, Michel E., Tersariol, Ivarne L. S., Almeida, Paulo C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121799/ https://www.ncbi.nlm.nih.gov/pubmed/21731773 http://dx.doi.org/10.1371/journal.pone.0021525

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