Disruption of the MDM2–p53 interaction strongly potentiates p53-dependent apoptosis in cisplatin-resistant human testicular carcinoma cells via the Fas/FasL pathway

Wild-type p53 has a major role in the response and execution of apoptosis after chemotherapy in many cancers. Although high levels of wild-type p53 and hardly any TP53 mutations are found in testicular cancer (TC), chemotherapy resistance is still observed in a significant subgroup of TC patients. I...

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Detalles Bibliográficos
Autores principales: Koster, R, Timmer-Bosscha, H, Bischoff, R, Gietema, J A, de Jong, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3122064/
https://www.ncbi.nlm.nih.gov/pubmed/21509038
http://dx.doi.org/10.1038/cddis.2011.33

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3122064/
https://www.ncbi.nlm.nih.gov/pubmed/21509038
http://dx.doi.org/10.1038/cddis.2011.33

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