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Elevated levels of urinary 8-hydroxy-2′-deoxyguanosine and 8-isoprostane in esophageal squamous cell carcinoma
AIMS: To measure oxidative DNA and lipid damages, urinary levels of 8-hydroxy-2′-deoxyguanosine (8-OHdG), and 8-isoprostane in esophageal squamous cell carcinoma (SCC) patients and compare the values with that in controls. MATERIALS AND METHODS: The urinary concentrations of 8-OHdG and 8-isoprostane...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3122113/ https://www.ncbi.nlm.nih.gov/pubmed/21712961 http://dx.doi.org/10.4103/1477-3163.79683 |
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author | Khadem-Ansari, Mohammad-Hassan Shahsavari, Zahra Rasmi, Yousef Mahmoodlo, Rahim |
author_facet | Khadem-Ansari, Mohammad-Hassan Shahsavari, Zahra Rasmi, Yousef Mahmoodlo, Rahim |
author_sort | Khadem-Ansari, Mohammad-Hassan |
collection | PubMed |
description | AIMS: To measure oxidative DNA and lipid damages, urinary levels of 8-hydroxy-2′-deoxyguanosine (8-OHdG), and 8-isoprostane in esophageal squamous cell carcinoma (SCC) patients and compare the values with that in controls. MATERIALS AND METHODS: The urinary concentrations of 8-OHdG and 8-isoprostane were measured in 32 SCC patients (13 female/19 male; mean age: 61.4 ± 10.5 years) and 45 controls (22 female/23 male; mean age: 58.1 ± 8.3 years). RESULTS: Squamous cell carcinoma patients showed significantly higher levels of urinary 8-OHdG (15.6 ± 5.1 ng/mg creatinine) than controls (5.8 ± 2.1 ng/mg creatinine) (P<.001). Increased urinary concentrations of 8-isoprostane were also detected in SCC patients (35.4 ± 6.5 ng/mmol creatinine) as compared to the controls (16.9 ± 4.0 ng/mmol creatinine) (P<.001). CONCLUSIONS: Our results show the presence of oxidative DNA and lipid damage in the SCC patients. This may have a connection to carcinogenesis in the esophagus. |
format | Online Article Text |
id | pubmed-3122113 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Medknow Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-31221132011-06-27 Elevated levels of urinary 8-hydroxy-2′-deoxyguanosine and 8-isoprostane in esophageal squamous cell carcinoma Khadem-Ansari, Mohammad-Hassan Shahsavari, Zahra Rasmi, Yousef Mahmoodlo, Rahim J Carcinog Original Article AIMS: To measure oxidative DNA and lipid damages, urinary levels of 8-hydroxy-2′-deoxyguanosine (8-OHdG), and 8-isoprostane in esophageal squamous cell carcinoma (SCC) patients and compare the values with that in controls. MATERIALS AND METHODS: The urinary concentrations of 8-OHdG and 8-isoprostane were measured in 32 SCC patients (13 female/19 male; mean age: 61.4 ± 10.5 years) and 45 controls (22 female/23 male; mean age: 58.1 ± 8.3 years). RESULTS: Squamous cell carcinoma patients showed significantly higher levels of urinary 8-OHdG (15.6 ± 5.1 ng/mg creatinine) than controls (5.8 ± 2.1 ng/mg creatinine) (P<.001). Increased urinary concentrations of 8-isoprostane were also detected in SCC patients (35.4 ± 6.5 ng/mmol creatinine) as compared to the controls (16.9 ± 4.0 ng/mmol creatinine) (P<.001). CONCLUSIONS: Our results show the presence of oxidative DNA and lipid damage in the SCC patients. This may have a connection to carcinogenesis in the esophagus. Medknow Publications 2011-04-16 /pmc/articles/PMC3122113/ /pubmed/21712961 http://dx.doi.org/10.4103/1477-3163.79683 Text en © 2011 Khadem-Ansari http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Khadem-Ansari, Mohammad-Hassan Shahsavari, Zahra Rasmi, Yousef Mahmoodlo, Rahim Elevated levels of urinary 8-hydroxy-2′-deoxyguanosine and 8-isoprostane in esophageal squamous cell carcinoma |
title | Elevated levels of urinary 8-hydroxy-2′-deoxyguanosine and 8-isoprostane in esophageal squamous cell carcinoma |
title_full | Elevated levels of urinary 8-hydroxy-2′-deoxyguanosine and 8-isoprostane in esophageal squamous cell carcinoma |
title_fullStr | Elevated levels of urinary 8-hydroxy-2′-deoxyguanosine and 8-isoprostane in esophageal squamous cell carcinoma |
title_full_unstemmed | Elevated levels of urinary 8-hydroxy-2′-deoxyguanosine and 8-isoprostane in esophageal squamous cell carcinoma |
title_short | Elevated levels of urinary 8-hydroxy-2′-deoxyguanosine and 8-isoprostane in esophageal squamous cell carcinoma |
title_sort | elevated levels of urinary 8-hydroxy-2′-deoxyguanosine and 8-isoprostane in esophageal squamous cell carcinoma |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3122113/ https://www.ncbi.nlm.nih.gov/pubmed/21712961 http://dx.doi.org/10.4103/1477-3163.79683 |
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