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Isthmin exerts pro-survival and death-promoting effect on endothelial cells through alphavbeta5 integrin depending on its physical state

Isthmin (ISM) is a 60 kDa secreted-angiogenesis inhibitor that suppresses tumor growth in mouse and disrupts vessel patterning in zebrafish embryos. It selectively binds to alphavbeta5 (αvβ5) integrin on the surface of endothelial cells (ECs), but the mechanism of its antiangiogenic action remains u...

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Detalles Bibliográficos
Autores principales:	Zhang, Y, Chen, M, Venugopal, S, Zhou, Y, Xiang, W, Li, Y-H, Lin, Q, Kini, R M, Chong, Y-S, Ge, R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2011
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3122116/ https://www.ncbi.nlm.nih.gov/pubmed/21544092 http://dx.doi.org/10.1038/cddis.2011.37

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