Involvement of lipid rafts in the localization and dysfunction effect of the antitumor ether phospholipid edelfosine in mitochondria

Lipid rafts and mitochondria are promising targets in cancer therapy. The synthetic antitumor alkyl-lysophospholipid analog edelfosine (1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine) has been reported to target lipid rafts. Here, we have found that edelfosine induced loss of mitochondrial me...

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Detalles Bibliográficos
Autores principales: Mollinedo, F, Fernández, M, Hornillos, V, Delgado, J, Amat-Guerri, F, Acuña, A U, Nieto-Miguel, T, Villa-Pulgarín, J A, González-García, C, Ceña, V, Gajate, C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3122120/
https://www.ncbi.nlm.nih.gov/pubmed/21593790
http://dx.doi.org/10.1038/cddis.2011.41

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