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Submaximal Inhibition of Protein Kinase C Restores ADP-induced Dense Granule Secretion in Platelets in the Presence of Ca(2+)

Protein kinase C (PKC) is a family of serine/threonine kinases that play isoform-specific inhibitory and stimulatory roles in platelet activation. We show here that the pan-PKC inhibitor Ro31-8220 can be used to dissect these events following platelet activation by ADP. Submaximal concentrations of...

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Detalles Bibliográficos
Autores principales:	Unsworth, Amanda J., Smith, Holly, Gissen, Paul, Watson, Steve P., Pears, Catherine J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2011
Materias:	Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3122168/ https://www.ncbi.nlm.nih.gov/pubmed/21489985 http://dx.doi.org/10.1074/jbc.M110.187138

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